Somi Health vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Somi Health
Best for low-cost compounded semaglutide or tirzepatide, plus an oral no-needle optionStarting at $135/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $212/mo
Side-by-Side Comparison
| Feature | Somi Health | Enhance MD |
|---|---|---|
| Overall Score | 7.6/10 | ✓8.6/10 |
| Starting Price | ✓$135/mo | $212/mo |
| Editorial Rating | 3.8 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Somi Health
What we like
- Among the lowest compounded prices: semaglutide $135/mo, tirzepatide $165/mo (3-month plan)
- Oral semaglutide tablet option for those who want no injections
- One price at any dose, with the medical visit and shipping included
- LegitScript Approved seal displayed; partnered with 503A pharmacies
- Free 2-5 day shipping; no insurance required
Watch-outs
- Compounded only - no brand-name Wegovy, Zepbound, Ozempic or Mounjaro
- Homepage advertises a 100% money-back guarantee but Terms state all sales are final, no refunds on medication
- Partner pharmacies are not individually named (material transparency gap)
- No single prescribing medical group named; only affiliated professional entities
- State availability not published; confirmed only during intake
Enhance MD
What we like
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- Unlimited clinician messaging and dose-adjustment support included
Watch-outs
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- No insurance accepted — cash pay, HSA/FSA eligible
- Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Somi Health with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Somi Health remains a solid alternative, especially if you're looking for low-cost compounded semaglutide or tirzepatide, plus an oral no-needle option.
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.