RxPepsDirect vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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RxPepsDirect
Best for: Lowest per-vial GLP-1 cost: compounded sema $25, tirz $45, $39 telehealth Rx, no subscription, 28 states
Visit RxPepsDirect →
Enhance MD
Best for: lab-monitored compounded GLP-1 with mandatory video visit
Visit Enhance MD →RxPepsDirect and Enhance MD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, RxPepsDirect starts lower at $64/mo versus $212/mo, and Enhance MD edges ahead overall (8.6 vs 7.0 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
RxPepsDirect
Verbatim: 'From $25/1.2mg' per vial (Semaglutide/B12). Per-vial model — not a recurring plan. At starter dose (0.25mg/week = ~1mg/month), one 1.2mg vial covers approximately 5 weeks. Monthly estimate: $25 vial + $39 visit fee = $64 first order; each refill also costs $39 visit + vial price. Shipping $15 flat FedEx overnight billed separately. Higher doses require multiple vials/month, increasing cost. No labs or coaching included.
Verbatim: 'From $45/12mg' per vial (Tirzepatide/B12). Per-vial model — not a recurring plan. At starter dose (2.5mg/week = 10mg/month), one 12mg vial covers approximately 5 weeks. Monthly estimate: $45 vial + $39 visit fee = $84 first order; each refill also costs $39 visit + vial price. Shipping $15 flat FedEx overnight billed separately. No labs or coaching included.
Enhance MD
What’s included
RxPepsDirect
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Billed separately
Enhance MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Not disclosed
Lab work
Included
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
RxPepsDirect
7.0/10
Enhance MD
8.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | RxPepsDirect | Enhance MD |
|---|---|---|
| Starting Price | ✓$64/mo | $212/mo |
| Features | ✓8 features | 6 features |
| States Available | 28 | ✓39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About RxPepsDirect
RxPepsDirect (Peptide RX LLC) is a per-vial compounded GLP-1 telehealth platform offering semaglutide/B12 from $25/vial and tirzepatide/B12 from $45/vial, dispensed through Optimal Balance Pharmacy (503A, Texas) after a $39 asynchronous online medical visit. Licensed NP/PA prescribers supervised by Medical Director Dr. Jonathan Snipes, MD issue patient-specific compounded Rx under the 503A pathway with no subscription required. FedEx overnight delivery, syringes, and travel case included; available in 28 states and DC.
Read our full RxPepsDirect review →About Enhance MD
Enhance MD pairs compounded semaglutide and tirzepatide with mandatory baseline metabolic labs at Quest Diagnostics and a synchronous video visit with a board-certified clinician — a more rigorous onboarding than the async-only compounded GLP-1 model most telehealth providers use. Three tiers (Core semaglutide, Advanced tirzepatide, Elite combined) plus aggressive intro pricing ($49 first month on Core).
Read our full Enhance MD review →Pros & Cons
RxPepsDirect
What we like
- Industry-lowest GLP-1 pricing: compounded semaglutide from $25/vial, tirzepatide from $45/vial — no subscription or recurring commitment required
- Real 503A telehealth Rx: licensed NP/PA prescribers + MD medical director (Dr. Jonathan Snipes, NPI 1821250077); patient-specific Rx dispensed by
- FedEx overnight shipping at $15 flat; ships pre-reconstituted and includes syringes, alcohol wipes, and reusable cooled travel case
- Independent batch COA testing by Eagle Analytical (FDA-registered, A2LA ISO 17025): 54/54 sterility and endotoxin passes published publicly on
- No subscription required; $39 flat visit fee covers up to 3 peptides per Rx; pay per vial with no ongoing commitment
Watch-outs
- No LegitScript certification; company founded 2026 — no public track record or long-term patient-outcomes data
- Minimal clinical oversight: $39 asynchronous intake form only — no live video consult required, no labs mandated, no monitoring protocol; lowest
- Per-vial pricing makes true monthly cost opaque; every refill costs another $39 visit fee on top of vial price and $15 shipping
- Only 28 states + DC; excludes California, most of the Southeast (AL, AR, GA, MS, NC, SC, TN, VA), and parts of Midwest
- No coaching, labs, dietitian support, or clinical monitoring included at any tier — purely prescription + dispensing
Enhance MD
What we like
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- Unlimited clinician messaging and dose-adjustment support included
Watch-outs
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- No insurance accepted — cash pay, HSA/FSA eligible
- Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out RxPepsDirect with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. RxPepsDirect remains a solid alternative, especially if you're looking for Lowest per-vial GLP-1 cost: compounded sema $25, tirz $45, $39 telehealth Rx, no subscription, 28 states.
Choose RxPepsDirect if…
You want Lowest per-vial GLP-1 cost: compounded sema $25, tirz $45, $39 telehealth Rx, no subscription, 28 states and a starting price around $64/mo.
Choose Enhance MD if…
You want lab-monitored compounded GLP-1 with mandatory video visit and a starting price around $212/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online, ranked by our editorial score.
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Live Vital
Shoppers who want low-cost, physician-led compounded GLP-1 with peptide and hormone options
From $99/mo
Get started →Bodybuilding Health+
Fitness-brand compounded GLP-1 with hormone and performance programs
From $179/mo
Get started →Gala
Compounded GLP-1/GIP combo therapy on a yearly subscription with free shipping nationwide
From $149/mo
Get started →RxPepsDirect vs Enhance MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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