NP2GO vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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NP2GO
Best for transparent per-dose pricing with pay-as-you-go or membership optionsStarting at $150/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | NP2GO | Enhance MD |
|---|---|---|
| Overall Score | 7.9/10 | ✓8.6/10 |
| Starting Price | $150/mo | ✓$49/mo |
| Editorial Rating | 4 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | ✓40 | 39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
NP2GO
Pros
- ✓Full per-dose pricing matrix published — you can see the cost at every dose tier before committing
- ✓Two pricing models (Pay As You Go and Month-to-Month Membership) let you match your usage pattern
- ✓Compounded semaglutide starts at $150/mo (0.25 mg, Pay As You Go) — competitive with the market low end
- ✓Covers 39 states plus DC
- ✓Files prior authorizations on your behalf — uncommon for compounded telehealth
- ✓Nurse-practitioner-led care with Obesity Medicine Association membership
Cons
- ✗High-dose tirzepatide runs $475–$600/mo on Pay As You Go (membership at $399/mo is better for high doses)
- ✗Not LegitScript-certified
- ✗Compounding pharmacy partner not named publicly
- ✗Not available in 11 states (AL, GA, IN, LA, MO, MS, NC, OH, SC, TN, WI)
- ✗Peptide, hormone, and aesthetic services are Oklahoma-only
- ✗$99 visit fee every 3 months (PAYG) is on top of the per-dose cost
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out NP2GO with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. NP2GO remains a solid alternative, especially if you're looking for transparent per-dose pricing with pay-as-you-go or membership options.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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