NewSelf vs RxPepsDirect
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →
RxPepsDirect
Best for: Lowest per-vial GLP-1 cost: sema $25, tirz $45, $39 telehealth Rx, 28 states
Visit RxPepsDirect →NewSelf and RxPepsDirect are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, RxPepsDirect starts lower at $64/mo versus $100/mo, and NewSelf edges ahead overall (8.3 vs 7.1 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
NewSelf
All dosages same price
All dosages same price
RxPepsDirect
Verbatim: 'From $25/1.2mg' per vial (Semaglutide/B12). Per-vial model — not a recurring plan. At starter dose (0.25mg/week = ~1mg/month), one 1.2mg vial covers approximately 5 weeks. Monthly estimate: $25 vial + $39 visit fee = $64 first order; each refill also costs $39 visit + vial price. Shipping $15 flat FedEx overnight billed separately. Higher doses require multiple vials/month, increasing cost. No labs or coaching included.
Verbatim: 'From $45/12mg' per vial (Tirzepatide/B12). Per-vial model — not a recurring plan. At starter dose (2.5mg/week = 10mg/month), one 12mg vial covers approximately 5 weeks. Monthly estimate: $45 vial + $39 visit fee = $84 first order; each refill also costs $39 visit + vial price. Shipping $15 flat FedEx overnight billed separately. No labs or coaching included.
Get alerted when GLP-1 prices drop
Join the GLP-1 price-watch list — we re-verify 480+ providers' prices on their own sites and email you when tracked prices move.
What’s included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
RxPepsDirect
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Billed separately
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.3/10
RxPepsDirect
7.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | NewSelf | RxPepsDirect |
|---|---|---|
| Starting Price | $100/mo | ✓$64/mo |
| Features | 6 features | ✓8 features |
| States Available | ✓49 | 28 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | 1 warning | ✓None |
About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →About RxPepsDirect
RxPepsDirect (Peptide RX LLC) is a per-vial compounded GLP-1 telehealth platform offering semaglutide/B12 from $25/vial and tirzepatide/B12 from $45/vial, dispensed through Optimal Balance Pharmacy (503A, Texas) after a $39 asynchronous online medical visit. Licensed NP/PA prescribers supervised by Medical Director Dr. Jonathan Snipes, MD issue patient-specific compounded Rx under the 503A pathway with no subscription required. FedEx overnight delivery, syringes, and travel case included; available in 28 states and DC.
Read our full RxPepsDirect review →Pros & Cons
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
RxPepsDirect
What we like
- Industry-lowest GLP-1 pricing: compounded semaglutide from $25/vial, tirzepatide from $45/vial — no subscription or recurring commitment required
- Real 503A telehealth Rx: licensed NP/PA prescribers + MD medical director (Dr. Jonathan Snipes, NPI 1821250077); patient-specific Rx dispensed by
- FedEx overnight shipping at $15 flat; ships pre-reconstituted and includes syringes, alcohol wipes, and reusable cooled travel case
- Independent batch COA testing by Eagle Analytical (FDA-registered, A2LA ISO 17025): 54/54 sterility and endotoxin passes published publicly on
- No subscription required; $39 flat visit fee covers up to 3 peptides per Rx; pay per vial with no ongoing commitment
Watch-outs
- No LegitScript certification; company founded 2026 — no public track record or long-term patient-outcomes data
- Minimal clinical oversight: $39 asynchronous intake form only — no live video consult required, no labs mandated, no monitoring protocol; lowest
- Per-vial pricing makes true monthly cost opaque; every refill costs another $39 visit fee on top of vial price and $15 shipping
- Only 28 states + DC; excludes California, most of the Southeast (AL, AR, GA, MS, NC, SC, TN, VA), and parts of Midwest
- No coaching, labs, dietitian support, or clinical monitoring included at any tier — purely prescription + dispensing
Our Verdict
NewSelf edges out RxPepsDirect with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. RxPepsDirect remains a solid alternative, especially if you're looking for Lowest per-vial GLP-1 cost: sema $25, tirz $45, $39 telehealth Rx, 28 states.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Choose RxPepsDirect if…
You want Lowest per-vial GLP-1 cost: sema $25, tirz $45, $39 telehealth Rx, 28 states and a starting price around $64/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Try Ageless
Lowest-tier compounded GLP-1 in injection, troche and sublingual forms
From $119/mo
Get started →Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
From $88/mo
Get started →MadeMed
Compounded GLP-1 in both injection and oral forms
From $219/mo
Get started →NewSelf vs RxPepsDirect: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring NewSelf and RxPepsDirect head-to-heads in the same category.
- NewSelf vs Amazon One Medical
- NewSelf vs Vytora Health
- NewSelf vs Collective
- RxPepsDirect vs CoreAge Rx
- RxPepsDirect vs EverSlim
- RxPepsDirect vs Found
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.