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Joi + Blokes vs Enhance MD

An in-depth comparison of two leading GLP-1 Providers

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8.0

Joi + Blokes

Best for GLP-1 alongside men's and women's hormone-health programs
★★★★☆4

Starting at $99/mo

CompoundedSemaglutideTirzepatideHealth Coaching
Visit Joi + Blokes →
8.6

Enhance MD

Best for lab-monitored compounded GLP-1 with mandatory video visit
★★★★☆4.3

Starting at $49/mo

CompoundedSemaglutideTirzepatideVideo Visit
Visit Enhance MD →

Side-by-Side Comparison

FeatureJoi + BlokesEnhance MD
Overall Score8.0/10✓8.6/10
Starting Price$99/mo✓$49/mo
Editorial Rating4 ★ /5✓4.3 ★ /5
Features✓7 features6 features
States Available0✓39
Compounded✓ Yes✓ Yes
Brand Name——
FSA/HSA Accepted——
FDA WarningsNoneNone

Pros & Cons

Joi + Blokes

Pros

  • ✓Separate programs for women (Joi) and men (Blokes) — most GLP-1 telehealth is gender-agnostic
  • ✓Trustpilot 4.6/5 from 1,254+ reviews — among the strongest review signals in the category
  • ✓Monthly price includes medication, dosing support, clinician consults, and health coaching
  • ✓Integrated hormone + GLP-1 programs help patients on testosterone or perimenopausal protocols
  • ✓First-month discount ($99 sema / $149 tirz) lowers the barrier to trying GLP-1s

Cons

  • ✗Billed quarterly — a 3-month commitment up front, not month-to-month
  • ✗Different pricing in NY and NJ — verify your state's cost before committing
  • ✗Per-state availability isn't listed; it's zip-code gated behind signup
  • ✗Months 2+ cost more ($199 sema / $299 tirz) than the headline intro price
  • ✗No FDA-approved Wegovy — compounded only on the GLP-1 side; Zepbound carries a separate visit fee
  • ✗No LegitScript or PCAB accreditation badge visible

Enhance MD

Pros

  • ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
  • ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
  • ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
  • ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
  • ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
  • ✓Unlimited clinician messaging and dose-adjustment support included

Cons

  • ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
  • ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
  • ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
  • ✗No insurance accepted — cash pay, HSA/FSA eligible
  • ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost

Our Verdict

Winner: Enhance MDScore: 8.6/10

Enhance MD edges out Joi + Blokes with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Joi + Blokes remains a solid alternative, especially if you're looking for GLP-1 alongside men's and women's hormone-health programs.

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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.