Fifty 410 vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Fifty 410
Best for Budget-focused buyers wanting transparent no-membership compounded GLP-1 pricingStarting at $99/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | Fifty 410 | Enhance MD |
|---|---|---|
| Overall Score | 7.0/10 | ✓8.6/10 |
| Starting Price | $99/mo | ✓$49/mo |
| Editorial Rating | 3.5 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warnings | None | None |
Pros & Cons
Fifty 410
Pros
- ✓Transparent public pricing from 99 dollars per month for semaglutide
- ✓No membership or subscription; pay only for what you need
- ✓Compounded by FDA-registered 503A and 503B pharmacies
- ✓Fast 24 to 48 hour provider review
- ✓Free one to two day shipping
- ✓Accepts FSA/HSA plus Afterpay and Affirm
Cons
- ✗Does not bill insurance directly
- ✗Compounded GLP-1 is not an FDA-approved finished drug
- ✗Specific clinician credentials are not publicly disclosed
- ✗Served-states list is not published on the site
- ✗No branded GLP-1 options
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Fifty 410 with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Fifty 410 remains a solid alternative, especially if you're looking for Budget-focused buyers wanting transparent no-membership compounded GLP-1 pricing.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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