Actin vs MEDVi
An in-depth comparison of two leading GLP-1 Providers
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Actin
Best for affordable compounded semaglutide with B12 enhancementStarting at $133/mo
MEDVi
Best for patients who want the option to switch between compounded and brand-name GLP-1 through one providerStarting at $179/mo
Side-by-Side Comparison
| Feature | Actin | MEDVi |
|---|---|---|
| Overall Score | 7.0/10 | ✓7.6/10 |
| Starting Price | ✓$133/mo | $179/mo |
| Editorial Rating | 3.5 ★ /5 | ✓3.8 ★ /5 |
| Features | 2 features | ✓7 features |
| States Available | 0 | ✓48 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Actin
Pros
- ✓Semaglutide + B12 combination for added energy support
- ✓Transparent pricing — exact cost shown upfront with no hidden fees
- ✓Competitive starting price from $133
Cons
- ✗Semaglutide only — no tirzepatide or liraglutide
- ✗No visible LegitScript or PCAB accreditation
- ✗State availability not disclosed
- ✗Broader platform (hormones, sexual wellness, hair health)
MEDVi
Pros
- ✓Both compounded and brand-name (Wegovy, Zepbound) GLP-1 options in one platform
- ✓Oral tablet and injectable formats
- ✓Named US pharmacy partners (Triad Rx, Precision Medicine, RedRock Pharmacy, Beaker Pharmacy & Compounding)
- ✓Clinical oversight through OpenLoop Health provider network and CareGLP Affiliated P.C.s
- ✓Direct-to-home shipping with 24/7 support
Cons
- ✗Refill price for compounded GLP-1 injection ($299) steps up significantly from $179 first-month offer
- ✗Not available in Mississippi or North Dakota (telehealth regulation constraints)
- ✗Alabama and California patients can only receive injectable formats, not tablets, per state law
- ✗Kansas, Indiana, New Mexico, Oklahoma, and West Virginia require a synchronous provider visit before prescribing
- ✗No LegitScript or PCAB certification disclosed on the site
Our Verdict
MEDVi edges out Actin with a higher overall score of 7.6/10 and is particularly strong for patients who want the option to switch between compounded and brand-name GLP-1 through one provider. Actin remains a solid alternative, especially if you're looking for affordable compounded semaglutide with B12 enhancement.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.