Actin vs Defy Medical
An in-depth comparison of two leading GLP-1 Providers
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Actin
Best for affordable compounded semaglutide with B12 enhancementStarting at $133/mo
Defy Medical
Best for Patients wanting GLP-1 in injection, ODT, or drop forms with thorough lab workupsSide-by-Side Comparison
| Feature | Actin | Defy Medical |
|---|---|---|
| Overall Score | ✓7.0/10 | 6.9/10 |
| Starting Price | $133/mo | — |
| Editorial Rating | 3.5 ★ /5 | 3.5 ★ /5 |
| Features | 3 features | ✓8 features |
| States Available | 0 | 0 |
| Compounded | ✓ Yes | — |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Actin
Pros
- ✓Semaglutide paired with B12 for added energy support
- ✓Transparent pricing — exact cost shown upfront with no hidden fees
- ✓Competitive starting price from $133
Cons
- ✗Semaglutide only — no tirzepatide or liraglutide
- ✗No visible LegitScript or PCAB accreditation
- ✗States served not disclosed
- ✗Broad platform spanning hormones, sexual wellness, and hair health
Defy Medical
Pros
- ✓Multiple GLP-1 options: semaglutide, tirzepatide, liraglutide
- ✓Offers injection, ODT, and oral drop delivery forms
- ✓Comprehensive blood testing and named medical director
- ✓Established clinic with strong Trustpilot review volume
Cons
- ✗GLP-1 pricing not published on the website
- ✗States served and shipping limits not disclosed
- ✗Compounded versus brand status not stated online
- ✗Lab-heavy, consult-first model may cost more upfront
Our Verdict
Actin edges out Defy Medical with a higher overall score of 7.0/10 and is particularly strong for affordable compounded semaglutide with B12 enhancement. Defy Medical remains a solid alternative, especially if you're looking for Patients wanting GLP-1 in injection, ODT, or drop forms with thorough lab workups.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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