1st Optimal vs YourHealthRx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
YourHealthRx
Best for: Science-forward GLP-1 and peptide care nationwide, with flat-rate dosing and built-in clinical follow-up
Visit YourHealthRx →1st Optimal and YourHealthRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, YourHealthRx starts at $170/mo, and YourHealthRx edges ahead overall (8.4 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
YourHealthRx
Weekly injectable + B12; $140 first month and on a 6-month plan. Oral dissolving tablet $180/mo. Flat price regardless of dose.
Weekly injectable + B12; $190 first month and on a 6-month plan. Oral dissolving tablet $220/mo. Flat price regardless of dose.
What’s included
1st Optimal
Inclusions not disclosed.
YourHealthRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
YourHealthRx
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | YourHealthRx |
|---|---|---|
| Starting Price | — | $170/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 51 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About YourHealthRx
YourHealthRx is a scientist-founded peptide and GLP-1 telehealth platform available in all 50 states and DC via a multi-state (IMLC) clinician network. Compounded semaglutide and tirzepatide come as a weekly injectable (with B12) or a daily oral tablet, at a flat subscription price that doesn't change with your dose - injectable semaglutide ~$170/mo and tirzepatide ~$210/mo ongoing. It also offers a broad peptide catalog plus lab testing. Prescribing runs through partner clinical workflows; compounded meds aren't FDA-approved, the pharmacy isn't named, and no LegitScript is shown.
Read our full YourHealthRx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
YourHealthRx
What we like
- Available in all 50 states and DC through a multi-state (IMLC) licensed clinician network
- Compounded semaglutide and tirzepatide in two formats - weekly injectable (with B12) or daily oral dissolving tablet
- Flat subscription price that doesn't change as your dose increases (no titration penalty)
- Science-forward, clinician-led, with built-in follow-up, lab testing, and a broad peptide and longevity catalog (BPC-157, TB-500, sermorelin, NAD+)
- Transparent, education-first positioning with published medical disclaimer, privacy, and terms
Watch-outs
- Eligibility and prescribing run through partner clinical workflows - YourHealthRx is the platform, not the prescriber or pharmacy
- Compounded medications are not FDA-approved - not brand Wegovy, Ozempic, Zepbound, or Mounjaro
- The compounding pharmacy partner is not named ('transparent sourcing' claimed but no pharmacy disclosed)
- Headline prices include a first-month intro rate; ongoing monthly cost is higher (semaglutide ~$170, tirzepatide ~$210)
- No LegitScript certification displayed
Our Verdict
YourHealthRx edges out 1st Optimal with a higher overall score of 8.4/10 and is particularly strong for Science-forward GLP-1 and peptide care nationwide, with flat-rate dosing and built-in clinical follow-up. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose YourHealthRx if…
You want Science-forward GLP-1 and peptide care nationwide, with flat-rate dosing and built-in clinical follow-up and a starting price around $170/mo.
Ready to start? Vetted GLP-1 providers
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Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →Live Vital
Shoppers who want low-cost, physician-led compounded GLP-1 with peptide and hormone options
From $99/mo
Get started →Bodybuilding Health+
Fitness-brand compounded GLP-1 with hormone and performance programs
From $179/mo
Get started →1st Optimal vs YourHealthRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.