1st Optimal vs Tyde Wellness
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Tyde Wellness
Best for: compounded GLP-1 with five named LegitScript-certified pharmacy partners
Visit Tyde Wellness →1st Optimal and Tyde Wellness are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Tyde Wellness starts at $119/mo, and Tyde Wellness edges ahead overall (8.0 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Tyde Wellness
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What’s included
1st Optimal
Inclusions not disclosed.
Tyde Wellness
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Not disclosed
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Tyde Wellness
8.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Tyde Wellness |
|---|---|---|
| Starting Price | — | $119/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Tyde Wellness
Tyde Wellness is a 50-state compounded-GLP-1 and longevity telehealth platform spanning weight loss, HRT, hair, and peptides. Its standout is supply-chain transparency — five named, LegitScript-certified 503A compounding pharmacy partners — plus a free consultation and a cancel-anytime subscription. Compounded semaglutide starts at $149/mo, tirzepatide at $249/mo, and low-dose naltrexone from $119/mo.
Read our full Tyde Wellness review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Tyde Wellness
What we like
- All 50 states served (full list published)
- Transparent pricing: semaglutide from $149/mo, tirzepatide from $249/mo
- LegitScript Certified with a verification link
- Five named 503A pharmacy partners with addresses: Belmar (CO), Casa (TX), Olympia (FL), Red Rock (UT), Beaker (TX)
- Free consultation; cancel-anytime subscription with no long-term commitment
- Microdose and full-strength options for both GLP-1s
- Single account covers weight loss, HRT, hair, and longevity peptides
Watch-outs
- Compounded semaglutide and tirzepatide are not FDA-approved finished products
- No brand-name GLP-1s (Wegovy, Zepbound, Mounjaro, Ozempic)
- Tirzepatide priced higher than competitors offering $200-$249/mo
- Corporate address and medical director not publicly disclosed
- No NABP .pharmacy seal visible
Our Verdict
Tyde Wellness edges out 1st Optimal with a higher overall score of 8.0/10 and is particularly strong for compounded GLP-1 with five named LegitScript-certified pharmacy partners. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Tyde Wellness if…
You want compounded GLP-1 with five named LegitScript-certified pharmacy partners and a starting price around $119/mo.
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SkinnyRx
Mainstream telehealth GLP-1 access
From $149.25/mo
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Compounded GLP-1 with unlimited telehealth visits and free shipping
From $159/mo
Get started →MadeMed
Compounded GLP-1 in both injection and oral forms
From $219/mo
Get started →1st Optimal vs Tyde Wellness: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.