1st Optimal vs TRT Kingdom
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
TRT Kingdom
Best for: Men or women wanting compounded GLP-1/GIP or microdosing within a TRT platform
Visit TRT Kingdom →1st Optimal and TRT Kingdom are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, both land at 6.7/10 overall. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
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Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
TRT Kingdom
6.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | TRT Kingdom |
|---|---|---|
| Starting Price | — | — |
| Features | ✓8 features | 7 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | — |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About TRT Kingdom
TRT Kingdom is a hormone-therapy telehealth platform (co-founded by bodybuilder Jay Cutler) offering TRT, peptides, weight loss, and wellness for men and women. Its weight-loss vertical is compounded GLP-1 and compounded GLP-1/GIP, including microdosing options. Medications are prescribed by a licensed physician and dispensed from an FDA-registered US pharmacy, though no pharmacy is named. CMO is Daniel Olivero, with NPs on staff. The site discloses that compounded GLP-1 and GLP-1/GIP medications are not FDA-approved or evaluated for safety or efficacy. Pricing and states are not published.
Read our full TRT Kingdom review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
TRT Kingdom
What we like
- Compounded GLP-1 and dual GLP-1/GIP options offered
- Microdosing protocols available for men and women
- Prescribed by licensed physician, dispensed from US pharmacy
- CMO (Daniel Olivero) plus nurse practitioners on staff
- Clear disclosure that compounded meds are not FDA-approved
Watch-outs
- Weight loss is secondary to core TRT/hormone focus
- No pricing published online
- Specific compounding pharmacy not named
- State licensing list not published
Our Verdict
Both 1st Optimal and TRT Kingdom score equally well overall — the right choice depends on your priorities.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose TRT Kingdom if…
You want Men or women wanting compounded GLP-1/GIP or microdosing within a TRT platform.
Ready to start? Vetted GLP-1 providers
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Telos Rx
Needle-free and microdosed compounded GLP-1 options with lab-monitored care
From $49/mo
Get started →GobyMeds
Budget-conscious shoppers
From $93/mo
Get started →RNK Health
Compounded GLP-1 alongside NAD+, peptide and longevity add-ons
From $197/mo
Get started →1st Optimal vs TRT Kingdom: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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