1st Optimal vs TrimRx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
1st Optimal and TrimRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, TrimRx starts at $179/mo, and TrimRx edges ahead overall (7.7 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
TrimRx
Homepage tier 'GLP-1 Starting at $179'; hero checkout mockup shows $299.00 list struck to $179.00/1st mo; email-capture popup offers '$120 OFF for your first order — GET YOUR FIRST MONTH AS LOW AS $135'. Multi-month bundle prices ($209/$191/$174 recorded 2026-07-10) are NO LONGER published — old public checkout 404s, plans now quiz-gated.
Homepage tier 'GLP-1 + GIP Starting at $259' (hero mockup: 'GLP-1 + GIP Medication Contains Tirzepatide') — DOWN from the $279 checkout limited offer we recorded 2026-07-10; bundle prices ($316/$299/$283) no longer published (quiz-gated).
'Mounjaro® Starting at $1249' homepage tile; same branded-fulfillment caveat.
'Zepbound® Starting at $1249' homepage tile; same branded-fulfillment caveat.
'Wegovy® Starting at $1579' homepage tile; same branded-fulfillment caveat.
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What’s included
1st Optimal
Inclusions not disclosed.
TrimRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
TrimRx
7.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | TrimRx |
|---|---|---|
| Starting Price | — | $179/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About TrimRx
TrimRx is a telehealth weight-loss program offering compounded semaglutide and tirzepatide prescribed by licensed US medical providers after an online medical-history review, with medication shipped monthly and free shipping. It leans on price stability and dose continuity — "switch and keep your current dose, no price hikes" — and needs no insurance (cash-pay, tiered monthly pricing plus multi-month bundles). Compounded GLP-1s are not FDA-approved. The compounding pharmacy and state list are not published, specifics are gated behind the intake quiz, and no LegitScript certification is shown.
Read our full TrimRx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
TrimRx
What we like
- Compounded semaglutide and tirzepatide, both prescribed by licensed US medical providers after an online medical-history review
- Free shipping with medication delivered to your door monthly — can start as soon as the next day
- Price-stability positioning: "switch and keep your current dose," with no advertised mid-program price hikes
- Tiered monthly pricing from ~$179/mo plus discounted multi-month bundles; no insurance required (cash-pay)
- 24/7 patient portal for support; publishes HIPAA, privacy, SMS, and terms policies
Watch-outs
- Async, questionnaire-based intake — no mandatory video visit with a clinician before prescribing
- Compounded semaglutide is not FDA-approved (the site discloses this) — it is not brand Wegovy or Ozempic
- Injectable-only — compounded semaglutide and tirzepatide are advertised, no oral form; program specifics are gated behind the intake quiz
- Compounding pharmacy partner is not named, and the state-availability list is not published
- Pricing tiers and program details are gated behind the intake quiz; no LegitScript certification displayed
Our Verdict
TrimRx edges out 1st Optimal with a higher overall score of 7.7/10 and is particularly strong for best overall value. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
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Get started →1st Optimal vs TrimRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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