1st Optimal vs TMates
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for Patients wanting GLP-1 therapy within a lab-driven functional-medicine programTMates
Best for nationwide compounded GLP-1 availability including Puerto RicoStarting at $199/mo
Side-by-Side Comparison
| Feature | 1st Optimal | TMates |
|---|---|---|
| Overall Score | ✓6.7/10 | 6.3/10 |
| Starting Price | — | $199/mo |
| Editorial Rating | ✓3.4 ★ /5 | 3.2 ★ /5 |
| Features | ✓8 features | 4 features |
| States Available | 0 | 0 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
1st Optimal
Pros
- ✓Offers both semaglutide and tirzepatide with injectable and oral formats
- ✓Functional-medicine approach with at-home labs and blood-work interpretation
- ✓Unlimited coaching and ongoing support included
- ✓No long-term contracts
- ✓Board-certified doctors and nurse practitioners referenced
Cons
- ✗No public monthly pricing disclosed
- ✗No published state availability list
- ✗Compounded vs branded sourcing not clarified on site
- ✗Pricing only revealed after quiz or consultation
TMates
Pros
- ✓All-inclusive monthly price covers medication, consults, nutrition coaching, and 24/7 support — no separate membership fee
- ✓Available in all 50 states plus Puerto Rico and other US territories
- ✓Both compounded semaglutide and tirzepatide offered
- ✓Fast stated turnaround — 2–3 days from intake to delivery
Cons
- ✗No third-party pharmacy accreditation (no LegitScript, PCAB, ACHC, or NABP)
- ✗BBB rating of B+ (not accredited) with complaints centered on billing and cancellation
- ✗Trustpilot reports of partial refunds and difficulty reaching support
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Pharmacy partners not named; routes medical and dispensing to third parties
- ✗Also sells testosterone and other wellness products — not GLP-1-focused
Our Verdict
1st Optimal edges out TMates with a higher overall score of 6.7/10 and is particularly strong for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. TMates remains a solid alternative, especially if you're looking for nationwide compounded GLP-1 availability including Puerto Rico.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.