1st Optimal vs TelePeptide
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
TelePeptide
Best for: All-in compounded GLP-1 (sema/tirz, injectable + oral) from $169/mo; LegitScript-certified, 48 states
Visit TelePeptide →1st Optimal and TelePeptide are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, TelePeptide starts at $169/mo, and TelePeptide edges ahead overall (8.2 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
TelePeptide
Verbatim from pricing page: Semaglutide Injectable $169/mo (annual prepay), $179/mo (6-month), $199/mo (monthly). All-inclusive — physician eval + Rx + medication + shipping.
Verbatim from pricing page: Tirzepatide Injectable $214/mo (annual prepay), $224/mo (6-month), $249/mo (monthly). All-inclusive — physician eval + Rx + medication + shipping.
Verbatim from pricing page: Semaglutide Dissolvable Tablet $199/mo (annual prepay), $209/mo (6-month), $229/mo (monthly). Oral sublingual formulation; all-inclusive.
Verbatim from pricing page: Tirzepatide Dissolvable Tablet $219/mo (annual prepay), $229/mo (6-month), $249/mo (monthly). Oral sublingual formulation; all-inclusive.
What’s included
1st Optimal
Inclusions not disclosed.
TelePeptide
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
TelePeptide
8.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | TelePeptide |
|---|---|---|
| Starting Price | — | $169/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About TelePeptide
TelePeptide is a LegitScript-certified US direct-pay telehealth practice offering physician-supervised compounded GLP-1 therapy — semaglutide and tirzepatide — in injectable and oral dissolvable tablet formulations across 48 states and DC (excluding Alaska and Mississippi). Every all-inclusive plan covers the physician evaluation, prescription, medication, and shipping from a 503A-licensed compounding pharmacy, with no insurance required and no hidden fees. The practice is operated under MD Integrations, P.C.
Read our full TelePeptide review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
TelePeptide
What we like
- LegitScript-certified (seal ID 49966407); 503A-licensed compounding pharmacies
- All-inclusive from $169/mo annual — physician eval + Rx + medication + shipping, no hidden fees
- Broadest formulation menu: injectable sema/tirz, oral dissolvable tablets, sema+naltrexone, microdose combos
- 24/7 care team messaging + regular check-ins + dosage adjustments included at every tier
- 48 states + DC coverage (excludes only AK + MS); no insurance required; cancel anytime
Watch-outs
- Compounded medications are not FDA-approved; no pharmacy partner named publicly
- Monthly billing costs more — $199/mo (monthly) vs $169/mo (annual) for semaglutide injectable; best rate requires annual prepay
- Labs not included in any plan
- Founder disclosed by first name only (Ahmed); no physician names or clinical leadership disclosed publicly
- Tirzepatide injectable at $249/mo (monthly billing) is above the compounded market average
Our Verdict
TelePeptide edges out 1st Optimal with a higher overall score of 8.2/10 and is particularly strong for All-in compounded GLP-1 (sema/tirz, injectable + oral) from $169/mo; LegitScript-certified, 48 states. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose TelePeptide if…
You want All-in compounded GLP-1 (sema/tirz, injectable + oral) from $169/mo; LegitScript-certified, 48 states and a starting price around $169/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online, ranked by our editorial score.
No insurance needed · vetted by our editors
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Telos Rx
Needle-free and microdosed compounded GLP-1 options with lab-monitored care
From $49/mo
Get started →Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →Live Vital
Shoppers who want low-cost, physician-led compounded GLP-1 with peptide and hormone options
From $99/mo
Get started →1st Optimal vs TelePeptide: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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