Best MOTS-c Providers in 2026 — Ranked & Reviewed

MOTS-c is a mitochondrial-derived peptide studied in mice as a metabolic regulator and “exercise mimetic.” No human randomized trial has tested MOTS-c as a weight-loss treatment, and it has no FDA approval for any use; see our full evidence review. In its draft enforcement policy of October 28, 2026, HHS says it does not intend to bring enforcement action against licensed 503A pharmacies and physicians that compound MOTS-c acetate for subcutaneous or intramuscular injection, subject to ten conditions. That changes where it can come from, not the evidence gap. See below for the current status.

Lowest verified price: $109/mo (Enhanced, ongoing rate)12 providers compared

New to MOTS-c? Read our full MOTS-c guide — evidence, dosing, safety and side effects.

MOTS-c dosage: what the FDA and published studies actually say.

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By Eli Marsden · Founding Editor
Editorially reviewed & fact-checked against primary sources · How we verify contentLast reviewed

12 mots-c providers compared · independently scored against our six-factor methodology.

Quick Picks: Top 5

#ProviderScore
1PeptiVisit
2Live VitalVisit
3OurView HealthVisit
4Ryze RxVisit
5EnhancedVisit

Status as of October 30, 2026

Under a draft HHS policy announced October 28, 2026, HHS says it will not take enforcement action against 503A pharmacies and physicians compounding MOTS-c under ten conditions. It is not FDA approval, and the policy is not final or binding; public comments are open until November 13, 2026.

Forms the policy covers
Injection (under the skin or into muscle) only. Other forms are labeled as not covered, and a clinic that does not state the form is marked that way.
Left off this list
Blends.
Key conditions
A patient-specific prescription, a single-ingredient product, a certificate of analysis from an FDA-registered manufacturer, and MedWatch reporting (ten conditions in all).
What a listing means
The clinic sells single-ingredient MOTS-c on its own site (checked October 30, 2026). We have not confirmed its pharmacy meets the policy's other conditions. Ask whether a 503A pharmacy (not a 503B outsourcing facility) fills your order, and in what device.
  • MOTS-c appeared on FDA's Category 2 list between September 29, 2023 and April 22, 2026. It is not FDA-approved, and no human trial has shown it causes weight loss.

More detail: how the HHS policy works.

Compare the top providers at a glance

Logos, our editorial rating, price, the form each clinic sells, and coverage. Forms outside the HHS policy are marked “not covered.”

  • ★ Editor's Pick
    Pepti
    From /mo
    $259
    Coverage
    50 states
    Form sold
    Injection
    Visit →
  • Nationwide Coverage
    Live Vital
    From /mo
    $200
    Coverage
    50 states
    Form sold
    Injection
    Visit →
  • OurView Health
    From /mo
    $130
    Coverage
    47 states
    Form sold
    Injection
    Visit →
  • Ryze Rx
    From /mo
    Check pricing
    Coverage
    Check intake
    Form sold
    Injection
    Visit →
  • Best Budget
    Enhanced
    From /mo
    $109
    Coverage
    Check intake
    Form sold
    Injection
    Visit →
  • EllieMD
    From /mo
    Check pricing
    Coverage
    Check intake
    Form sold
    Injection
    Visit →
  • RxPepsDirect
    From /mo
    Check pricing
    Coverage
    28 states
    Form sold
    Injection
    Visit →
  • Rewinding RX
    From /mo
    Check pricing
    Coverage
    50 states
    Form sold
    Injection
    Visit →
  • ElitePhysiqMD
    From /mo
    $401
    Coverage
    Check intake
    Form sold
    Injection
    Visit →
  • Scripts Rx Direct

    compounded peptides priced up front, including KPV, MOTS-c, epitalon and semax nasal spray

    From /mo
    $170
    Coverage
    Check intake
    Form sold
    Injection
    Visit →
  • Joey Med
    From /mo
    Check pricing
    Coverage
    50 states
    Form sold
    Injection
    Visit →
  • Royal Medical Center
    From /mo
    Check pricing
    Coverage
    Check intake
    Form sold
    Form not stated
    Visit →
6scored dimensions
12MOTS-c providers compared

Each checked against the provider’s own site.

Value 25%Effectiveness 25%User Experience 15%Trust & Safety 15%Accessibility 10%Support 10%

Providers that don’t post pricing up front score lower on Value and carry a cost-transparency note in their review. Read the full methodology →

Detailed Reviews

A note on prices below: any dollar figure in these provider summaries refers to that clinic’s GLP‑1 weight-loss program, not to MOTS-c. The MOTS-c price is the one beside each clinic in the comparison table above, read from that clinic’s own product page. Where it reads “Check pricing”, the clinic prescribes MOTS-c but publishes no price for it — you are quoted after the consultation.

1

Pepti

7.9

Pepti is a Delaware-registered telehealth platform selling doctor-prescribed compounded peptides and GLP-1s, with a published shipping list of 49 states plus DC. Injectable semaglutide starts at $99 and tirzepatide at $159 per 28-day supply, rising with dose to $199 and $319. Each price covers medication, physician review, labs, refill management and shipping, with no membership fee. Pepti is a platform, not a prescriber, and does not bill insurance.

Score Breakdown

Value25%
8.5
Effectiveness25%
7.5
User Experience15%
8.5
Trust & Safety15%
7
Accessibility10%
8.5
Support10%
7.5

Pros

  • ✓Injectable semaglutide starts at $99 and tirzepatide at $159 all-in, with no membership fee on top.
  • ✓Publishes the exact price for every dose of both drugs, so you can see what titrating up will cost before you start.
  • ✓Publishes a shipping list of 49 states plus DC, and a provider denial means a full refund.
  • ✓Names the reviewing physician, Dr. Gene Lee MD, and posts third-party sterility and potency results by lot.

Cons

  • ✗Billed every 28 days rather than monthly, so you pay 13 times a year, not 12.
  • ✗Price rises with dose: semaglutide tops out at $199 and tirzepatide at $319 per supply.
  • ✗The site says it serves 50 states, but its own list leaves out Oklahoma and counts DC instead.
  • ✗No compounding pharmacy is named in advance; you only learn it from your medication label.
  • ✗The listed address, a Newark Delaware suite, is a shared registered-agent address rather than a clinical office.
  • ✗Cash-pay only with no insurance billing, and medication can't be refunded once it ships.
Starting from $259/moForm soldInjectionRead full review →
Visit Pepti →
2

Live Vital

Verified partner
7.7

Live Vital is a physician-led telehealth practice founded by Dr. Patrick Taylor, MD, offering compounded GLP-1 weight loss (semaglutide advertised from $99/mo and tirzepatide from $183/mo, both sold as 10-week protocols) alongside peptide and hormone therapy. Every plan is doctor-prescribed, filled by a licensed US pharmacy, and shipped to your door, with unlimited care-team messaging. Fully telehealth in all 50 states.

Score Breakdown

Value25%
8.5
Effectiveness25%
7.5
User Experience15%
6.5
Trust & Safety15%
7.3
Accessibility10%
8.5
Support10%
8

Pros

  • ✓Physician-led: founded by Dr. Patrick Taylor, MD; all treatments doctor-prescribed via the clinical team
  • ✓Transparent published pricing: semaglutide from $99/mo, tirzepatide from $183/mo, both on 10-week protocols
  • ✓Every plan includes doctor prescribing, licensed-pharmacy medication, and direct-to-door shipping
  • ✓Unlimited messaging with the care team; you can cancel at any time, effective at the end of the current billing period
  • ✓Fully telehealth in all 50 states

Cons

  • ✗The advertised '/mo' rate divides a 10-week protocol by three, so a calendar month costs about $130 or $239
  • ✗Doesn't accept insurance (HSA/FSA funds only)
  • ✗Compounding pharmacy isn't named (only 'a licensed US pharmacy')
  • ✗Medications and lab work are generally non-refundable once ordered, and consultation refunds are at the practice's discretion
  • ✗Also a peptide/longevity practice; those peptides are not FDA-approved (the site discloses this)
Starting from $200/moForm soldInjectionRead full review →
Visit Live Vital →
3

OurView Health

7.4

OurView Health is an online telehealth platform for weight loss, hormone therapy and wellness, with care from licensed providers through the Telegra network. Compounded semaglutide is $109/mo and tirzepatide $129/mo at any prescribed dose, or $99 and $119/mo on a 3-month prepay, with no membership or shipping fee. Medication is compounded by Boudreaux's New Drug Store, a 503A pharmacy in Louisiana. Service covers 46 states plus DC.

Score Breakdown

Value25%
8
Effectiveness25%
7.5
User Experience15%
7
Trust & Safety15%
6.8
Accessibility10%
7.5
Support10%
7.4

Pros

  • ✓Low flat pricing: compounded semaglutide $109/mo and tirzepatide $129/mo at any prescribed dose
  • ✓No membership fee and free shipping; a 3-month prepay drops the price to $99 or $119/mo
  • ✓Names its pharmacy (Boudreaux's New Drug Store, a Louisiana 503A) and provider network (Telegra)
  • ✓LegitScript seal on the site and a published list of states served
  • ✓No contracts; your card is only charged after a provider approves treatment

Cons

  • ✗Not available in Arkansas, Connecticut, Hawaii or New Jersey
  • ✗Only 1-month or 3-month plans; the 3-month price is paid upfront
  • ✗All sales are final once medication ships
  • ✗The website is run by a marketing agency (Kickstart Social), and the operating company isn't named
  • ✗Terms set Georgia law but require arbitration in San Diego, California
Starting from $130/moForm soldInjectionRead full review →
Visit OurView Health →
4

Ryze Rx

7.4

Ryze Rx is a prescription telehealth platform for weight loss, TRT and peptide therapy, prescribing through board-certified physicians and shipping from US-licensed compounding pharmacies. For weight loss it offers compounded injectable semaglutide and tirzepatide at $199/mo (or $499/$799 for a 3-month bundle), with physician consult and shipping included. The homepage advertises care in all 50 states.

Score Breakdown

Value25%
8
Effectiveness25%
7.5
User Experience15%
7
Trust & Safety15%
6.3
Accessibility10%
8
Support10%
7

Pros

  • ✓Compounded semaglutide and tirzepatide both $199/mo, with $499/$799 three-month bundles
  • ✓Physician consultation, ongoing clinical support and discreet shipping included with each prescription
  • ✓Broad catalog beyond GLP-1: TRT plus peptides (BPC-157, sermorelin, NAD+, retatrutide and more)
  • ✓Free shipping, 24hr prescription turnaround, FSA/HSA eligible; care advertised in all 50 states

Cons

  • ✗Terms, Privacy Policy and HIPAA notice are dead links, so no legal entity, refund policy or governing law is disclosed
  • ✗Pharmacy partners not named beyond 'US-licensed compounding pharmacies'
  • ✗Homepage advertises GLP-1s 'from $149/mo' but the catalog lists $199/mo
  • ✗On-site '4.9/5, 2,400+ reviews' is self-reported, not an independently confirmed rating
Check pricingForm soldInjectionRead full review →
Visit Ryze Rx →
5

Enhanced

7.2

Enhanced, the brand behind the Enhanced Games, now sells clinician-prescribed compounded semaglutide and tirzepatide through independent telehealth providers, plus six newly launched peptide programs. Semaglutide is $129 month to month and tirzepatide $169, at every standard dose, falling to $89 and $129 on a 12-month plan billed upfront. Testosterone, supplements and other treatments sit alongside them.

Score Breakdown

Value25%
7.8
Effectiveness25%
7.5
User Experience15%
7
Trust & Safety15%
6.5
Accessibility10%
7
Support10%
6.5

Pros

  • ✓Semaglutide from $129 month to month, or $89 a month on a 12-month plan
  • ✓Tirzepatide from $169 month to month, or $129 a month on a 12-month plan
  • ✓Partner pharmacies named: Red Rock, Health Warehouse, Precision Medicine and Triad Rx
  • ✓Terms hold an advertised 'forever' price while you stay active on the same plan
  • ✓Same price at every standard dose, with medication, clinician review and shipping listed as included
  • ✓Six peptide programs, each from $119 month to month

Cons

  • ✗The lowest standard-plan prices require paying for 12 months upfront: $1,068 for semaglutide, $1,548 for tirzepatide
  • ✗Canceling only stops the next renewal; terms give no refund for the unused part of a billing period
  • ✗Advertised 12-month savings use a list price; against its own monthly rate the real saving is $480
  • ✗Shipping can take at least 10 business days; peptides 2-3 weeks
  • ✗No state list published; availability is confirmed during intake
  • ✗Prescribers are independent and not named until intake; no phone support listed
  • ✗Compounded medications are not FDA-approved
  • ✗Money-back guarantee has strict conditions, and Enhanced decides whether a request qualifies
Starting from $109/moForm soldInjectionRead full review →
Visit Enhanced →
How we rank & what counts as “legit”

Every provider in this ranking is scored against our published six-factor rubric[1] — value, effectiveness, user experience, trust & safety, accessibility, and support.

Brand-name Wegovy, Zepbound, Ozempic, and Mounjaro are separately FDA-approved under their own NDA numbers[4][5]. Published Phase 3 efficacy for semaglutide 2.4 mg (~14.9% mean weight loss over 68 weeks) comes from the STEP 1 trial[6], and for tirzepatide (~20.9% at the 15 mg dose over 72 weeks) from SURMOUNT-1[7]; the SURMOUNT-5 head-to-head published in 2025 compared the two directly[8].

Insurance coverage for anti-obesity medications varies widely by state Medicaid program and commercial plan[9][10]. Compounded and brand-name GLP-1s are generally FSA/HSA eligible with a prescription under IRS Publication 502[11].

Always verify pricing and state availability on the provider's website before signing up.How our reviews work →

Frequently Asked Questions

Each provider is evaluated across six weighted dimensions: Value (25%), Effectiveness (25%), User Experience (15%), Trust & Safety (15%), Accessibility (10%), and Support (10%). We research publicly available information, user reviews, clinical evidence, and pricing data, then compute a weighted overall score out of 10.
Each provider's score is computed independently using the six-dimension methodology, and a commercial relationship never changes a provider's underlying score — you can see every provider's full score on its card. Some providers have affiliate agreements with us, meaning we earn a commission if you click through and make a purchase. On our highest-commercial-intent lists — including the semaglutide, tirzepatide, compounded and cheapest molecule lists, the weight-loss injection and shot lists, and the fitness-app list — we feature affiliate partners in the top positions; on every other list the order follows the score (or, for the cheapest lists, the lowest price) directly. This placement is disclosed here and on our methodology and affiliate-disclosure pages.
Sources & methodology (as of November 2026)
  1. 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
  2. 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
  3. 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
  4. 4.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  5. 5.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  6. 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
  7. 7.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
  8. 8.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
  9. 9.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
  10. 10.CMS — Medicaid prescription drug coverage policy (state-by-state)— Centers for Medicare & Medicaid Services.
  11. 11.IRS Publication 502 — Medical and Dental Expenses (HSA/FSA eligibility)— Internal Revenue Service.

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