Health outcomes & conditions

GLP-1s, Mental Health, Cravings & the Brain

GLP-1 receptors sit in the brain as well as the gut, which is why these drugs come up in conversations about food noise, cravings, alcohol and nicotine, mood, and memory. This cluster collects the articles on the brain-and-behavior side of GLP-1 therapy, from the FDA and EMA suicidality reviews to the early addiction and dementia research, with the strength of each line of evidence spelled out.

38 research articles · newest update October 2026

Recently updated

Semaglutide for Antipsychotic Weight Gain: What the Clozapine and Olanzapine Trials Show

Semaglutide is now the best-studied add-on for antipsychotic weight gain. In two randomized trials of people on clozapine, olanzapine and similar drugs, it took off about 9 kg more than placebo without worsening symptoms. The trials, metformin and clozapine safety.

10 min read · Updated October 2026

Night Eating Syndrome: Diagnostic Criteria, Treatment and GLP-1 Evidence

Night eating syndrome: the diagnostic criteria, how common it is with obesity, how it differs from binge eating disorder and sleep-related eating disorder, what trials show for sertraline and CBT, and what is and is not known about GLP-1 drugs and evening eating.

10 min read · Updated October 2026

CBT for Weight Loss Alongside a GLP-1: What the Evidence Shows

Cognitive behavioral therapy is the most studied psychological approach to weight, and its effect is real but modest. Why that modesty is an argument for pairing it with a GLP-1 rather than choosing between them.

7 min read · Updated September 2026

GLP-1 Drugs and Binge Eating: Treatment Target or Masking Risk?

Binge eating disorder overlaps heavily with the population taking GLP-1 drugs. There is genuine scientific interest in GLP-1 signaling as a treatment target, and a genuine risk of the drug hiding a disorder. Both deserve saying plainly.

7 min read · Updated September 2026

All 38 articles in this topic

Most recently updated first.

  1. Semaglutide for Antipsychotic Weight Gain: What the Clozapine and Olanzapine Trials Show10 min · October 2026
  2. Night Eating Syndrome: Diagnostic Criteria, Treatment and GLP-1 Evidence10 min · October 2026
  3. CBT for Weight Loss Alongside a GLP-1: What the Evidence Shows7 min · September 2026
  4. GLP-1 Drugs and Binge Eating: Treatment Target or Masking Risk?7 min · September 2026
  5. Antidepressants and Weight on a GLP-1: SSRIs, SNRIs, Wellbutrin, and What the Evidence Actually Shows15 min · August 2026
  6. Body Dysmorphia, Disclosure & Post-Loss Grief on GLP-1 (2026): The Psychosocial Side of Rapid Weight Loss15 min · August 2026
  7. Cortisol Belly Fat on a GLP-1: Honest Evidence Review12 min · August 2026
  8. Do GLP-1s Stop Sugar & Sweet Cravings?8 min · August 2026
  9. Does Anxiety Cause Weight Loss? Evidence Review (Mechanism, GI Symptoms, Sleep)14 min · August 2026
  10. Does Nicotine Help with Weight Loss? Evidence Review (Mechanism, Risks)14 min · August 2026
  11. Does Vaping Cause Weight Loss? Evidence Review (Mechanism, EVALI, Addiction)15 min · August 2026
  12. EVOKE + EVOKE Plus: Semaglutide for Early Alzheimer's Disease11 min · August 2026
  13. GLP-1 + Adderall, Vyvanse, or Ritalin: The Stacking Evidence12 min · August 2026
  14. GLP-1 + Naltrexone for AUD: The Stacking Evidence12 min · August 2026
  15. GLP-1 and Mood/Depression: The Evidence (2026)12 min · August 2026
  16. GLP-1 Brain Fog: What the Cognitive Studies Actually Show11 min · August 2026
  17. GLP-1 Drugs and Alcohol Use Disorder: What the Trial Evidence Actually Shows in 202613 min · August 2026
  18. GLP-1 Food Noise: The Brain Science Explained11 min · August 2026
  19. GLP-1 for Binge Eating Disorder: Vyvanse Comparison and Stacking Evidence11 min · August 2026
  20. GLP-1 for Opioid Use Disorder: Buprenorphine and Methadone Evidence11 min · August 2026
  21. GLP-1 for Parkinson's Disease: Exenatide + Lixisenatide Trials11 min · August 2026
  22. GLP-1 for Smoking Cessation: Chantix, Bupropion, and Nicotine Stacking11 min · August 2026
  23. GLP-1 Weight Loss and Body Image: The Mental Side9 min · August 2026
  24. GLP-1 With Lithium, Lamictal, or Atypical Antipsychotics11 min · August 2026
  25. GLP-1 With PTSD: Prazosin, Prolonged Exposure, Stellate Ganglion11 min · August 2026
  26. GLP-1s & Mental Health (2026): What the FDA's January 2026 Suicidality Warning Removal Means for Mood, Anhedonia & Depression14 min · August 2026
  27. GLP-1s for Alzheimer's & Dementia Prevention: Patient Guide12 min · August 2026
  28. How to Handle Food Pushers on a GLP-19 min · August 2026
  29. I Don't Enjoy Eating Anymore: Losing Food Joy on a GLP-19 min · August 2026
  30. Mounjaro and Mental Health: Mood, Depression & Suicidal Thoughts — What the Evidence Says (2026)8 min · August 2026
  31. Ozempic and Mental Health: Mood, Depression & Suicidal Thoughts — What the Evidence Says (2026)8 min · August 2026
  32. Stress, Cortisol, and Weight on a GLP-1: What the Evidence Actually Shows12 min · August 2026
  33. Vyvanse, Adderall, and Stimulants for Weight: What the Evidence Shows (And Why Most of It Is Off-Label)12 min · August 2026
  34. GLP-1 and Addiction Circuitry: Alcohol, Nicotine, More (2026)12 min · July 2026
  35. Ozempic Personality Change & Anhedonia: Honest Evidence Review13 min · July 2026
  36. Does Tirzepatide / Semaglutide Cause Depression? FDA Postmarket Surveillance + Evidence Review13 min · July 2026
  37. GLP-1 and Suicidality: FDA & EMA Review Findings (2026)13 min · July 2026
  38. Does Wegovy Cause Depression? GLP-1 Mental Health Evidence Review14 min · July 2026