Refills vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Refills
Best for single account across GLP-1, ED and hair-growth telehealthEnhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | Refills | Enhance MD |
|---|---|---|
| Overall Score | 6.9/10 | ✓8.6/10 |
| Starting Price | — | $49/mo |
| Editorial Rating | 3.5 ★ /5 | ✓4.3 ★ /5 |
| Features | 6 features | 6 features |
| States Available | 0 | ✓39 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Refills
Pros
- ✓LegitScript Certified online pharmacy
- ✓Claims operation across all 50 states (with some exclusions)
- ✓Multi-category platform (weight loss + ED + hair growth + wellness) — single account for multiple treatments
- ✓Free shipping disclosed publicly
- ✓Cash-pay, no insurance needed
Cons
- ✗Ongoing monthly pricing for compounded semaglutide and tirzepatide not shown until after intake
- ✗Legal entity name and state of incorporation not disclosed
- ✗Compounding pharmacy partner not named
- ✗Excluded states not listed in marketing copy — verify coverage during intake
- ✗Compounded only — no brand-name GLP-1 (Wegovy, Zepbound, Mounjaro, Ozempic, Foundayo)
- ✗Lab work and ongoing-care touchpoints not clearly disclosed
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Refills with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Refills remains a solid alternative, especially if you're looking for single account across GLP-1, ED and hair-growth telehealth.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.