Primary Clinic (Direct GLP) vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Primary Clinic (Direct GLP)
Best for GLP-1 at wholesale cost inside a Direct Primary Care membershipStarting at $65/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | Primary Clinic (Direct GLP) | Enhance MD |
|---|---|---|
| Overall Score | 8.0/10 | ✓8.6/10 |
| Starting Price | $65/mo | ✓$49/mo |
| Editorial Rating | 4 ★ /5 | ✓4.3 ★ /5 |
| Features | 4 features | ✓6 features |
| States Available | 10 | ✓39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Primary Clinic (Direct GLP)
Pros
- ✓Direct Primary Care model integrates GLP-1 with continuous primary care — unlike most direct-to-consumer platforms
- ✓GLP-1 at wholesale cost with no markup — semaglutide from $65/mo, tirzepatide from $110/mo (members only)
- ✓Unlimited primary care visits, direct text access, and same-day care bundled in the $89/mo membership
- ✓Routine labs and thousands of medications included in membership — no surprise bills
- ✓Per-dose pricing shown publicly for all 8 dose tiers of both semaglutide and tirzepatide
- ✓Publishes the FDA 503A compounded-medication disclaimer
Cons
- ✗10 states only (WA, NM, AZ, UT, FL, DC, KS, OK, VA, GA) — limited vs 50-state platforms
- ✗Membership required to access wholesale pricing — $89/mo adds ~$1,068/yr in fixed cost
- ✗503A pharmacy partners not named
- ✗LegitScript certification not mentioned on the site
- ✗Medical director and corporate legal entity not disclosed
- ✗Compounded only — no brand-name Wegovy, Ozempic, Mounjaro, or Zepbound
- ✗Refund policy not disclosed publicly
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Primary Clinic (Direct GLP) with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Primary Clinic (Direct GLP) remains a solid alternative, especially if you're looking for GLP-1 at wholesale cost inside a Direct Primary Care membership.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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