Premium Health vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Premium Health
Best for Buyers wanting an all-inclusive compounded GLP-1 membership with named pharmaciesStarting at $275/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | Premium Health | Enhance MD |
|---|---|---|
| Overall Score | 6.7/10 | ✓8.6/10 |
| Starting Price | $275/mo | ✓$49/mo |
| Editorial Rating | 3.4 ★ /5 | ✓4.3 ★ /5 |
| Features | 6 features | 6 features |
| States Available | 0 | ✓39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Premium Health
Pros
- ✓All-inclusive membership covers medication, supplies, shipping, and provider visits
- ✓LegitScript certified with verification seal
- ✓Names three licensed pharmacy partners (Hallandale, Red Rock, Strive)
- ✓Compounded with Vitamin B12 or B6 to aid tolerance
- ✓Free consultation and HIPAA-compliant telehealth via Doxy.me
- ✓Includes nutrition and fitness plans plus community access
Cons
- ✗Compounded medications are not FDA-approved
- ✗Higher base pricing than many compounded competitors ($275/$445)
- ✗High-dose tiers cost extra ($100-$150/mo)
- ✗States available not specified on site
- ✗Cash-pay only; no insurance noted
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Premium Health with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Premium Health remains a solid alternative, especially if you're looking for Buyers wanting an all-inclusive compounded GLP-1 membership with named pharmacies.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.