PlushCare vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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PlushCare
Best for readers who want a primary-care relationship with GLP-1 prescribing as one option, AND who read the class-action disclosure and verify the cancellation flow before subscribingStarting at $149/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | PlushCare | Enhance MD |
|---|---|---|
| Overall Score | 7.0/10 | ✓8.6/10 |
| Starting Price | $149/mo | ✓$49/mo |
| Editorial Rating | 3.5 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓7 features | 6 features |
| States Available | ✓50 | 39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
PlushCare
Pros
- ✓All 50 states per the homepage
- ✓Appointments with US board-certified physicians (not nurse practitioners only)
- ✓Operates as virtual primary care, so the same provider can write GLP-1 prescriptions alongside other primary-care needs
- ✓Owned by Transcarent (post-Accolade-acquisition), a venture-backed health platform with named corporate parent
Cons
- ✗ACTIVE LITIGATION: California class action alleging deceptive subscription enrollment and unauthorized post-cancellation charges on the $19.99/month membership. Material disclosure for any reader signing up.
- ✗GLP-1 prescribing is clinician-discretionary at the visit level — not a guaranteed offering at intake
- ✗BBB rating reflects an ongoing pattern of complaints around the membership cancellation flow
Enhance MD
Pros
- ✓Baseline and ongoing metabolic lab panels (CMP, lipids, TSH, HbA1c) at Quest Diagnostics every 6 months — a rigor most compounded GLP-1 providers skip entirely
- ✓Mandatory one-on-one video visit with a US-licensed MD or NP before the first prescription — not a pure-async questionnaire model
- ✓Three pricing tiers including a combined semaglutide + tirzepatide Elite plan ($322/mo ongoing) — useful for patients plateaued on a single GLP-1
- ✓LegitScript-certified 503A pharmacy network: Tru Meds Rx, Strive Pharmacy, Pharmacy Hub
- ✓Aggressive first-month intro pricing: $49 on Core, $99 on Advanced, $189 on Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro option
- ✗Not available in 10 states: Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, South Carolina, Tennessee, West Virginia
- ✗Mandatory lab work adds 5–10 days to onboarding vs. async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗First-month intro pricing resets to full tier rate after 30 days — the $49/$99/$189 numbers are not the ongoing cost
Our Verdict
Enhance MD edges out PlushCare with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. PlushCare remains a solid alternative, especially if you're looking for readers who want a primary-care relationship with GLP-1 prescribing as one option, AND who read the class-action disclosure and verify the cancellation flow before subscribing.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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