Peptivo vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Peptivo
Best for Budget shoppers wanting low-cost online GLP-1 with same-day visits and free shippingEnhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $212/mo
Side-by-Side Comparison
| Feature | Peptivo | Enhance MD |
|---|---|---|
| Overall Score | 7.2/10 | ✓8.6/10 |
| Starting Price | — | $212/mo |
| Editorial Rating | 3.6 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓39 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warnings | None | None |
Pros & Cons
Peptivo
What we like
- Low entry pricing — GLP-1 weight-loss plans starting at $169/mo, with free discreet shipping
- Same-day provider visits and 24/7 provider messaging; 100% online
- Compounded in the USA at FDA-registered labs; can also prescribe brand GLP-1 (Ozempic, Wegovy, Zepbound)
- FSA/HSA eligible with upfront pricing
Watch-outs
- GLP-1 products use generic names ('GLP-1 Daily Support', 'Weight Loss Boost') — semaglutide/tirzepatide not clearly broken out
- Compounding pharmacy/lab partner not named
- Limited published policies (privacy and terms only; no HIPAA notice or refund policy found)
- Not LegitScript-certified (no certification displayed)
Enhance MD
What we like
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- Unlimited clinician messaging and dose-adjustment support included
Watch-outs
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- No insurance accepted — cash pay, HSA/FSA eligible
- Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Peptivo with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Peptivo remains a solid alternative, especially if you're looking for Budget shoppers wanting low-cost online GLP-1 with same-day visits and free shipping.
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.