Medi-Weightloss vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Medi-Weightloss
Best for Patients wanting in-person physician-supervised GLP-1 care with insurance/HSA useStarting at $199/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | Medi-Weightloss | Enhance MD |
|---|---|---|
| Overall Score | 7.2/10 | ✓8.6/10 |
| Starting Price | $199/mo | ✓$49/mo |
| Editorial Rating | 3.6 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓39 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warnings | None | None |
Pros & Cons
Medi-Weightloss
Pros
- ✓Both branded (Wegovy, Zepbound) and compounded semaglutide/tirzepatide
- ✓Established brand with 130+ physician-supervised locations nationwide
- ✓Telehealth plus in-person clinic options
- ✓Accepts insurance at many locations; HSA/FSA welcome
- ✓Includes body-composition analysis and personalized plans
Cons
- ✗Ongoing medication pricing not transparently posted; varies by plan
- ✗$199 new-patient visit fee before medication costs
- ✗Frequent (often weekly) visits expected for some patients
- ✗Compounded products are not FDA-approved or evaluated
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Medi-Weightloss with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Medi-Weightloss remains a solid alternative, especially if you're looking for Patients wanting in-person physician-supervised GLP-1 care with insurance/HSA use.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.