LevelUp Rx vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
LevelUp Rx
Best for compounded semaglutide and tirzepatide at a flat price with named pharmaciesStarting at $149.97/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $212/mo
Side-by-Side Comparison
| Feature | LevelUp Rx | Enhance MD |
|---|---|---|
| Overall Score | 7.5/10 | ✓8.6/10 |
| Starting Price | ✓$149.97/mo | $212/mo |
| Editorial Rating | 3.8 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
LevelUp Rx
What we like
- Compounded semaglutide ($149.97/mo) and tirzepatide ($249.97/mo) on one platform
- Flat monthly price that never changes with your dose
- No-cost online consultation included with your order
- LegitScript-certified; partner pharmacies named (DiRx and The DrugStore)
- Free shipping with no insurance required
- Published patient-care phone line and email support
Watch-outs
- Compounded only - no brand-name Wegovy, Zepbound, Ozempic or Mounjaro
- No single prescribing medical group named; physicians listed only for CA, MA, RI and VT
- State availability is confirmed during intake, not published as a list
- Prescription sales are final once shipped; no returns on dispensed medication
Enhance MD
What we like
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- Unlimited clinician messaging and dose-adjustment support included
Watch-outs
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- No insurance accepted — cash pay, HSA/FSA eligible
- Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out LevelUp Rx with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. LevelUp Rx remains a solid alternative, especially if you're looking for compounded semaglutide and tirzepatide at a flat price with named pharmacies.
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring LevelUp Rx and Enhance MD head-to-heads in the same category.
- LevelUp Rx vs CoreAge Rx
- LevelUp Rx vs TrimRx
- LevelUp Rx vs Amazon One Medical
- Enhance MD vs NovoCare Pharmacy
- Enhance MD vs Vytora Health
- Enhance MD vs Noom Med
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.