Always verify pricing and state availability on the provider's website before signing up.How our reviews work →

GetRelief Rx vs Enhance MD

An in-depth comparison of two leading GLP-1 Providers

WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more

6.1

GetRelief Rx

Best for buyers specifically seeking sublingual (non-injectable) compounded GLP-1 drops who understand the bioavailability trade-offs and lack of human PK data for this formulation
★★★☆☆3.1

Starting at $179/mo

Compounded SemaglutideCompounded TirzepatideSublingual OnlyBBB Accredited
Visit GetRelief Rx →
8.6

Enhance MD

Best for lab-monitored compounded GLP-1 with mandatory video visit
★★★★☆4.3

Starting at $49/mo

CompoundedSemaglutideTirzepatideQuest Diagnostics Labs Included
Visit Enhance MD →

Side-by-Side Comparison

FeatureGetRelief RxEnhance MD
Overall Score6.1/10✓8.6/10
Starting Price$179/mo✓$49/mo
Editorial Rating3.1 ★ /5✓4.3 ★ /5
Features5 features✓6 features
States Available0✓39
Compounded✓ Yes✓ Yes
Brand Name——
FSA/HSA Accepted——
FDA WarningsNoneNone

Pros & Cons

GetRelief Rx

Pros

  • ✓Both compounded semaglutide and tirzepatide available at publicly displayed pricing — no login wall to see costs
  • ✓BBB accredited with A rating (March 2026); NPI 1306697834 is independently verifiable
  • ✓Free online assessment — no upfront consultation fee before prescribing decision

Cons

  • ✗SUBLINGUAL ONLY — no injectable option. Sublingual compounded semaglutide and tirzepatide have NOT been tested in human pharmacokinetic studies; mouse models suggest 5-8x higher doses needed to match subcutaneous bioavailability. Readers should understand this is NOT the same delivery method studied in STEP/SURMOUNT trials.
  • ✗REGULATORY FLAG: GetReliefRX continues to offer compounded tirzepatide as of April 2026, after FDA ended enforcement discretion for tirzepatide compounding (March 19, 2025 for 503B, April 22, 2025 for 503A). The legal basis may be state-level exemptions, but this is not publicly disclosed on the site.
  • ✗No LegitScript, PCAB, or NABP certifications identified — BBB accreditation is not a pharmacy-specific compliance credential
  • ✗Prescriber credentials are described generically as 'licensed clinicians' without specifying MD/DO/NP/PA breakdown

Enhance MD

Pros

  • ✓Baseline and ongoing metabolic lab panels (CMP, lipids, TSH, HbA1c) at Quest Diagnostics every 6 months — a rigor most compounded GLP-1 providers skip entirely
  • ✓Mandatory one-on-one video visit with a US-licensed MD or NP before the first prescription — not a pure-async questionnaire model
  • ✓Three pricing tiers including a combined semaglutide + tirzepatide Elite plan ($322/mo ongoing) — useful for patients plateaued on a single GLP-1
  • ✓LegitScript-certified 503A pharmacy network: Tru Meds Rx, Strive Pharmacy, Pharmacy Hub
  • ✓Aggressive first-month intro pricing: $49 on Core, $99 on Advanced, $189 on Elite
  • ✓Unlimited clinician messaging and dose-adjustment support included

Cons

  • ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro option
  • ✗Not available in 10 states: Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, South Carolina, Tennessee, West Virginia
  • ✗Mandatory lab work adds 5–10 days to onboarding vs. async-only competitors
  • ✗No insurance accepted — cash pay, HSA/FSA eligible
  • ✗First-month intro pricing resets to full tier rate after 30 days — the $49/$99/$189 numbers are not the ongoing cost

Our Verdict

Winner: Enhance MDScore: 8.6/10

Enhance MD edges out GetRelief Rx with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. GetRelief Rx remains a solid alternative, especially if you're looking for buyers specifically seeking sublingual (non-injectable) compounded GLP-1 drops who understand the bioavailability trade-offs and lack of human PK data for this formulation.

Get Started with GetRelief Rx →Get Started with Enhance MD →

Glossary references

Key terms in this article, linked to their canonical definitions.

Related comparisons

Continue exploring GetRelief Rx and Enhance MD head-to-heads in the same category.

Or see the full category ranking.

Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.