Genesis Lifestyle Medicine vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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Genesis Lifestyle Medicine
Best for hybrid med-spa GLP-1 with 18 clinics and brand-name accessEnhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | Genesis Lifestyle Medicine | Enhance MD |
|---|---|---|
| Overall Score | 6.6/10 | ✓8.6/10 |
| Starting Price | — | $49/mo |
| Editorial Rating | 3.3 ★ /5 | ✓4.3 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 8 | ✓39 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Genesis Lifestyle Medicine
Pros
- ✓18 physical clinics allow in-person consults and injections across 8 states
- ✓Dual modality — compounded sema/tirz plus brand-name Wegovy and Zepbound on one platform
- ✓Med spa model lets patients combine weight loss, hormone therapy, and aesthetics
- ✓Established brand with an 18-location footprint and patient testimonials
- ✓Telehealth available for remote patients in served states
- ✓LegitScript verified
Cons
- ✗Pricing not disclosed publicly — gated behind the consultation flow
- ✗Specific 503A/503B pharmacy partner not named, and the designation not specified
- ✗No FDA compounded-medication disclaimer visible on the homepage
- ✗Named medical director not formally disclosed (only a 'Dr. Spinoso' testimonial)
- ✗Corporate legal entity and governing law not disclosed
- ✗Only 8 states served — much narrower than national competitors
- ✗Telehealth runs on a separate domain, fragmenting the brand trail
Enhance MD
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Low first-month intro pricing: $49 Core, $99 Advanced, $189 Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro pricing resets to full tier rate after 30 days — the $49/$99/$189 figures aren't ongoing cost
Our Verdict
Enhance MD edges out Genesis Lifestyle Medicine with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. Genesis Lifestyle Medicine remains a solid alternative, especially if you're looking for hybrid med-spa GLP-1 with 18 clinics and brand-name access.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.