Actin vs Cielo
An in-depth comparison of two leading GLP-1 Providers
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Actin
Best for affordable compounded semaglutide with B12 enhancementStarting at $133/mo
Cielo
Best for Price-sensitive patients who want flat-rate compounded semaglutide or tirzepatide on a 3-month commitment and don't require a publicly disclosed pharmacy partner or accreditation badgeStarting at $115/mo
Side-by-Side Comparison
| Feature | Actin | Cielo |
|---|---|---|
| Overall Score | 7.0/10 | ✓7.5/10 |
| Starting Price | $133/mo | ✓$115/mo |
| Editorial Rating | 3.5 ★ /5 | ✓3.8 ★ /5 |
| Features | 2 features | ✓9 features |
| States Available | 0 | 0 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Actin
Pros
- ✓Semaglutide + B12 combination for added energy support
- ✓Transparent pricing — exact cost shown upfront with no hidden fees
- ✓Competitive starting price from $133
Cons
- ✗Semaglutide only — no tirzepatide or liraglutide
- ✗No visible LegitScript or PCAB accreditation
- ✗State availability not disclosed
- ✗Broader platform (hormones, sexual wellness, hair health)
Cielo
Pros
- ✓Among the lowest 3-month-bundle prices in compounded GLP-1 segment ($115/mo semaglutide)
- ✓Single flat price across all doses simplifies titration planning
- ✓Transparent corporate address (St. Petersburg, FL) and customer-service phone published
Cons
- ✗No publicly disclosed LegitScript, NABP .pharmacy, or HIPAA badge on home page
- ✗Named pharmacy partner not disclosed publicly (only 'Regulated FDA pharmacy partners')
- ✗State coverage list not published — cannot verify all-50-state availability
- ✗MD Integrations is a third-party clinical-affiliations network used by many compounded-GLP-1 brands (not a dedicated medical group), reducing structural differentiation
- ✗No brand-name Wegovy/Zepbound option for patients who want FDA-approved manufacturer fulfillment
- ✗Donation page displays '0%' next to the 10%-pledge claim (apparent discrepancy noted on home page)
Our Verdict
Cielo edges out Actin with a higher overall score of 7.5/10 and is particularly strong for Price-sensitive patients who want flat-rate compounded semaglutide or tirzepatide on a 3-month commitment and don't require a publicly disclosed pharmacy partner or accreditation badge. Actin remains a solid alternative, especially if you're looking for affordable compounded semaglutide with B12 enhancement.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.