24hrDOC vs Synergy Rx
An in-depth comparison of two leading GLP-1 Providers
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24hrDOC
Best for Cash-pay patients wanting fast, low-cost compounded semaglutide or tirzepatideStarting at $149/mo
Synergy Rx
Best for broadest drug catalog in the Lion MD white-label clusterStarting at $199/mo
Side-by-Side Comparison
| Feature | 24hrDOC | Synergy Rx |
|---|---|---|
| Overall Score | 7.1/10 | ✓7.4/10 |
| Starting Price | ✓$149/mo | $199/mo |
| Editorial Rating | 3.6 ★ /5 | ✓3.7 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | 0 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
24hrDOC
Pros
- ✓Low compounded semaglutide price, around 149 per month
- ✓Fast model: 10-minute assessment, Rx within 45 minutes
- ✓Injectable and oral semaglutide plus tirzepatide options
- ✓24/7 availability with unlimited provider messaging
Cons
- ✗Compounded only, not FDA-approved branded GLP-1s
- ✗Self-pay only, no insurance accepted
- ✗States served not disclosed on the site
- ✗Fast-prescribing model offers less in-depth clinical workup
Synergy Rx
Pros
- ✓Broad catalog: compounded sema/tirz in injection and oral dissolving tablet, plus brand Ozempic, Wegovy, and Mounjaro
- ✓Claims 50,000+ patients as of late 2025
- ✓Available in all 50 states, subject to state telehealth rules
- ✓Same medical team as Breeze Meds and Care Bare Rx (Dr. Carr and Dr. Tenbrink via Lion MD)
- ✓Four named 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma Rx)
- ✓LegitScript Certified
Cons
- ✗Same clinician network and pharmacies as Breeze Meds and Care Bare Rx — three brands on one underlying operation
- ✗Mandatory individual arbitration + class-action waiver (30-day opt-out from signup)
- ✗Consultation fees non-refundable and all prescription sales final
- ✗Disclaims liability for third-party pharmacy medication quality
- ✗Full active-state list requires contacting support, not published
- ✗Correct site is synergyrx.co — synergyrx.com is an unrelated parked domain
Our Verdict
Synergy Rx edges out 24hrDOC with a higher overall score of 7.4/10 and is particularly strong for broadest drug catalog in the Lion MD white-label cluster. 24hrDOC remains a solid alternative, especially if you're looking for Cash-pay patients wanting fast, low-cost compounded semaglutide or tirzepatide.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.