1st Optimal vs Zeuss
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Zeuss
Best for: the only one-time-purchase, no-subscription compounded GLP-1 model
Visit Zeuss →1st Optimal and Zeuss are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Zeuss starts at $125/mo, and Zeuss edges ahead overall (7.1 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Zeuss
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What’s included
1st Optimal
Inclusions not disclosed.
Zeuss
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Zeuss
7.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Zeuss |
|---|---|---|
| Starting Price | — | $125/mo |
| Features | ✓8 features | 4 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Zeuss
Zeuss is a multi-vertical telehealth platform offering compounded semaglutide and tirzepatide for weight loss alongside TRT, HRT, skin, and hair services. Its genuine differentiator is a no-subscription, one-time-purchase model — no auto-renewals or memberships, with a full refund if a physician can't prescribe. Bundled pricing covers provider review, medication, and cold-chain shipping; GLP-1 starts at $125/mo and tirzepatide at $175/mo.
Read our full Zeuss review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Zeuss
What we like
- One-time-purchase model with no subscription — genuinely rare among DTC GLP-1 providers
- Publishes the FDA compounded-medication disclaimer
- Names both 503A and 503B compounding pathways — uncommon transparency
- Bundled pricing covers provider review, meds, and cold-chain shipping with no hidden fees
- Full refund if a physician can't prescribe
- $125/mo starting price, competitive with the broader DTC market
- Temperature-controlled cold-chain shipping disclosed
- Gender-segmented Body services for patients who prefer male- or female-focused framing
Watch-outs
- 503A pharmacy partner not named (only generic '503A and 503B state-licensed' framing)
- LegitScript certification not mentioned
- No named medical director or physician leadership
- Full states-served list not disclosed
- Corporate legal entity not disclosed
- Governing law and arbitration venue not disclosed
- GLP-1 pages live at awkward URLs (/services/body-for-him/ and /services/body-for-her/)
- Corporate physical address not disclosed
Our Verdict
Zeuss edges out 1st Optimal with a higher overall score of 7.1/10 and is particularly strong for the only one-time-purchase, no-subscription compounded GLP-1 model. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Zeuss if…
You want the only one-time-purchase, no-subscription compounded GLP-1 model and a starting price around $125/mo.
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Breeze Meds
Compounded GLP-1 access with named prescribers and 4-pharmacy network
From $169/mo
Get started →Telos Rx
Needle-free and microdosed compounded GLP-1 options with lab-monitored care
From $49/mo
Get started →GobyMeds
Budget-conscious shoppers
From $93/mo
Get started →1st Optimal vs Zeuss: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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