1st Optimal vs YourEra
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
1st Optimal and YourEra are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, YourEra starts at $99/mo, and YourEra edges ahead overall (6.9 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
YourEra
Site advertises 'As low as $99/month — same price at every dose' (July 2026; earlier first-month framing dropped). Exact standing rate confirmed at intake.
Same $99 'as low as' price advertised for weekly semaglutide or tirzepatide injections.
Get alerted when GLP-1 prices drop
Join the GLP-1 price-watch list — we re-verify 390+ providers' prices on their own sites and email you when tracked prices move.
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
YourEra
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | YourEra |
|---|---|---|
| Starting Price | — | $99/mo |
| Features | ✓8 features | 4 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About YourEra
YourEra is a LegitScript-certified telehealth platform offering compounded semaglutide and tirzepatide injections starting at $99 for the first month, with ongoing pricing set after the medical intake. Care runs entirely online, with doctor visits and prescriptions handled remotely. The site is upfront that these compounded medications are not the brand-name drugs Ozempic, Wegovy, Mounjaro, or Zepbound — a candid bit of transparency for the category.
Read our full YourEra review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
YourEra
What we like
- $99 first-month entry pricing for compounded GLP-1 — among the cheapest in the market
- LegitScript Certified
- Clearly states it's 100% online doctor visits and prescriptions
- Honest that the compounded medications aren't brand-name Ozempic, Wegovy, Mounjaro, or Zepbound
Watch-outs
- Ongoing maintenance-dose price isn't published — ask before committing
- Legal entity name and state of incorporation aren't disclosed
- Pharmacy partners not named — only "state-licensed pharmacies"
- Per-state availability not listed; verify your state ships before buying
- Initial consultation fee not disclosed
- Lab work and ongoing-care details aren't spelled out
Our Verdict
YourEra edges out 1st Optimal with a higher overall score of 6.9/10 and is particularly strong for $99 first-month entry pricing on compounded GLP-1s. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose YourEra if…
You want $99 first-month entry pricing on compounded GLP-1s and a starting price around $99/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Breeze Meds
Compounded GLP-1 access with named prescribers and 4-pharmacy network
From $169/mo
Get started →Telos Rx
Needle-free and microdosed compounded GLP-1 options with lab-monitored care
From $49/mo
Get started →GobyMeds
Budget-conscious shoppers
From $93/mo
Get started →1st Optimal vs YourEra: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring 1st Optimal and YourEra head-to-heads in the same category.
- 1st Optimal vs Amazon One Medical
- 1st Optimal vs Vytora Health
- 1st Optimal vs CoreAge Rx
- YourEra vs EverSlim
- YourEra vs Found
- YourEra vs NewSelf
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.