1st Optimal vs Telos Rx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Telos Rx
Best for: Needle-free, microdosed compounded GLP-1 with lab-monitored care
Visit Telos Rx →1st Optimal and Telos Rx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Telos Rx starts at $99/mo, and Telos Rx edges ahead overall (7.4 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Telos Rx
Site: 'As low as $99 per month' standing (struck-through $299), 'first month from $49'. Exact per-tier standing prices shown at intake.
Site: 'As low as $139 per month' standing (struck-through $399), first month as low as $99.
Published standing tiers: 1-mo $229 / 3-mo $159 / 6-mo $139 / 12-mo $129 per month; 'Starting from $49 first month'.
Published standing tiers: 1-mo $279 / 3-mo $234 / 6-mo $219 / 12-mo $199 per month; 'Starting from $69 first month'.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Telos Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Telos Rx
7.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Telos Rx |
|---|---|---|
| Starting Price | — | $99/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Telos Rx
Telos Rx is a compounded telehealth platform (Superior Health Solutions LLC) offering GLP-1 weight loss alongside longevity, recovery, and sexual-health peptides. Its GLP-1 line includes compounded semaglutide and tirzepatide injections plus needle-free sublingual and microdosed tirzepatide, with provider dose adjustments, lab monitoring, free discreet shipping, FSA/HSA, and cancel-anytime. Headline prices are first-month intro rates (from $49); ongoing cost is higher. Compounded meds are not FDA-approved; pharmacy and states unpublished; no LegitScript shown.
Read our full Telos Rx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Telos Rx
What we like
- Multiple GLP-1 modalities: compounded semaglutide and tirzepatide injections plus needle-free sublingual and microdosed tirzepatide
- Provider-led dose adjustments and lab monitoring as your protocol changes
- Free discreet, temperature-controlled shipping (no Telos branding on the outside)
- FSA/HSA eligible and cancel anytime in one click
- Trustpilot rating of 4.9; full compliance suite published (Privacy, Terms, HIPAA, Shipping & returns)
- Integrated care team spanning weight loss, longevity, recovery, and sexual health (peptide-led)
Watch-outs
- Headline pricing is 'first month low as' intro pricing (semaglutide $49, tirzepatide $99) — ongoing monthly cost is higher and shown during intake
- Compounded medications are not FDA-approved (the site discloses this) — not brand Wegovy, Ozempic, Zepbound, or Mounjaro
- Compounding pharmacy partner is not named
- State-availability list is not published
- No LegitScript certification displayed
Our Verdict
Telos Rx edges out 1st Optimal with a higher overall score of 7.4/10 and is particularly strong for Needle-free, microdosed compounded GLP-1 with lab-monitored care. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program.
Choose Telos Rx if…
You want Needle-free, microdosed compounded GLP-1 with lab-monitored care and a starting price around $99/mo.
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Wellorithm
Compounded GLP-1 access with oral tablet options across 49 states
From $147/mo
Get started →SkinnyRx
Mainstream telehealth GLP-1 access
From $149.25/mo
Get started →YourEra
$99 first-month entry pricing on compounded GLP-1s
From $99/mo
Get started →1st Optimal vs Telos Rx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.