1st Optimal vs Superpower
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Superpower
Best for: Members who want lab testing bundled with a GLP-1 prescription, not just medication
Visit Superpower →1st Optimal and Superpower are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Superpower starts at $199/mo, and Superpower edges ahead overall (7.1 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Superpower
Marketing 'from' price on superpower.com/semaglutide; the standalone Marketplace product listing for the same compounded semaglutide shows $229/mo. Separate from the $199/year membership fee.
Brand Ozempic 'from' price shown alongside the compounded option on the same page; same bimonthly upfront-billing cadence applies.
Get alerted when GLP-1 prices drop
Join the GLP-1 price-watch list — we re-verify 430+ providers' prices on their own sites and email you when tracked prices move.
What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Superpower
What the monthly price covers
Medication
Included
Provider visits
Not disclosed
Shipping
Not disclosed
Lab work
Included
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Superpower
7.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Superpower |
|---|---|---|
| Starting Price | — | $199/mo |
| Features | ✓8 features | 7 features |
| States Available | Not disclosed | 42 |
| Compounded | — | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Superpower
Superpower is a $199-per-year health membership built around twice-yearly 100+ biomarker lab testing, not a single-purpose GLP-1 shop. Members who are clinically appropriate can add prescription treatments -- including compounded semaglutide or brand-name Ozempic -- through Superpower's in-house Marketplace, billed separately from the membership fee. Pharmacy fulfillment runs through named partners Strive Pharmacy, Belmar Pharmacy, and Progress Pharmacy.
Read our full Superpower review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Superpower
What we like
- Twice-yearly 100+ biomarker lab testing bundled into every membership, not just a GLP-1 prescription mill
- Named compounding pharmacy partners: Strive Pharmacy, Belmar Pharmacy, and Progress Pharmacy
- 30-day money-back guarantee on the GLP-1 medication itself if it isn't a fit
- Real, claimed Trustpilot profile: 4.6/5 from 309 reviews
- Both compounded semaglutide and brand-name Ozempic offered on one page
- Available in 42 of 51 US jurisdictions (50 states + DC) per its own published list
- 24/7 care team access claimed, plus a published members@superpower.com support contact
Watch-outs
- Two separate $199 charges with different meanings ($199/year membership vs. 'from $199/month' medication) risk confusing shoppers
- GLP-1 'from $199/month' is billed every 2 months, paid upfront in full -- not a true monthly charge
- Marketplace list price for the same compounded semaglutide is $229/mo, above the landing-page 'from' figure
- $199/year membership fee is non-refundable even though the medication carries a 30-day guarantee
- LegitScript certification is only a text claim on-site; no verifiable seal or badge image was found
- No health insurance accepted
- Mandatory binding arbitration and class-action waiver in the Terms of Service
- Not available in Alaska, Arkansas, Hawaii, Louisiana, Mississippi, North Dakota, Rhode Island, South Dakota, or Wyoming
Our Verdict
Superpower edges out 1st Optimal with a higher overall score of 7.1/10 and is particularly strong for Members who want lab testing bundled with a GLP-1 prescription, not just medication. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program.
Choose Superpower if…
You want Members who want lab testing bundled with a GLP-1 prescription, not just medication and a starting price around $199/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
MadeMed
Compounded GLP-1 in both injection and oral forms
From $219/mo
Get started →Oak
Compounded semaglutide and tirzepatide at a flat monthly price
From $119/mo
Get started →Bodybuilding Health+
Fitness-brand compounded GLP-1 with hormone and performance programs
From $179/mo
Get started →1st Optimal vs Superpower: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring 1st Optimal and Superpower head-to-heads in the same category.
- 1st Optimal vs Amazon One Medical
- 1st Optimal vs Vytora Health
- 1st Optimal vs CoreAge Rx
- Superpower vs EverSlim
- Superpower vs Found
- Superpower vs NewSelf
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.