1st Optimal vs Somi Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Somi Health
Best for: low-cost compounded semaglutide or tirzepatide, plus an oral no-needle option
Visit Somi Health →1st Optimal and Somi Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Somi Health starts at $135/mo, and Somi Health edges ahead overall (7.7 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Somi Health
$135/mo on the 3-month plan, 'ANY DOSE.' Verified joinsomi.com 2026-06-19.
$165/mo on the 3-month plan, 'ANY DOSE.' Verified joinsomi.com 2026-06-19.
Semaglutide Tablet (no shots), $279/mo on the 1-month plan. Verified joinsomi.com 2026-06-19.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Somi Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Somi Health
7.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Somi Health |
|---|---|---|
| Starting Price | — | $135/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Somi Health
Somi Health is a telehealth weight-loss provider offering compounded GLP-1 medications - compounded semaglutide and tirzepatide injections plus an oral semaglutide tablet. A US-licensed clinician reviews a short online intake, and one transparent monthly price covers the medical visit, ongoing medication shipments and direct provider messaging. Compounded semaglutide starts at $135/mo and tirzepatide at $165/mo on the 3-month plan, one price at any dose.
Read our full Somi Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Somi Health
What we like
- Among the lowest compounded prices: semaglutide $135/mo, tirzepatide $165/mo (3-month plan)
- Oral semaglutide tablet option for those who want no injections
- One price at any dose, with the medical visit and shipping included
- LegitScript Approved seal displayed; partnered with 503A pharmacies
- Free 2-5 day shipping; no insurance required
Watch-outs
- Compounded only - no brand-name Wegovy, Zepbound, Ozempic or Mounjaro
- Homepage advertises a 100% money-back guarantee but Terms state all sales are final, no refunds on medication
- Partner pharmacies are not individually named (material transparency gap)
- No single prescribing medical group named; only affiliated professional entities
- State availability not published; confirmed only during intake
Our Verdict
Somi Health edges out 1st Optimal with a higher overall score of 7.7/10 and is particularly strong for low-cost compounded semaglutide or tirzepatide, plus an oral no-needle option. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program.
Choose Somi Health if…
You want low-cost compounded semaglutide or tirzepatide, plus an oral no-needle option and a starting price around $135/mo.
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Get started →1st Optimal vs Somi Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.