Best Semax Providers in 2026 — Ranked & Reviewed
Semax is a synthetic seven-amino-acid analog of an ACTH fragment, developed in Russia and studied mainly as a nasal preparation. In rats it raises brain-derived neurotrophic factor (BDNF); the human studies are small Russian papers in stroke, motor neuron disease and optic-nerve disease, not trials of cognitive enhancement in healthy people. The draft HHS enforcement policy of October 28, 2026 covers licensed 503A pharmacies and physicians compounding semax only as a nasal product, and only when ten conditions are met. That is enforcement discretion, not FDA approval. See below for the current status.
Lowest verified price: $109/mo (OurView Health, ongoing rate)7 providers compared
New to Semax? Read our full Semax guide — evidence, dosing, safety and side effects.
Semax dosage: what the FDA and published studies actually say.
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7 semax providers compared · independently scored against our six-factor methodology.
Status as of October 30, 2026
Under a draft HHS policy announced October 28, 2026, HHS says it will not take enforcement action against 503A pharmacies and physicians compounding semax under ten conditions. It is not FDA approval, and the policy is not final or binding; public comments are open until November 13, 2026.
- Forms the policy covers
- Intranasal only. Injectable semax is not covered and is labeled that way.
- Left off this list
- Semax and selank combination sprays.
- Key conditions
- A patient-specific prescription, a single-ingredient product, a certificate of analysis from an FDA-registered manufacturer, and MedWatch reporting (ten conditions in all).
- What a listing means
- The clinic sells single-ingredient semax on its own site (checked October 30, 2026). We have not confirmed its pharmacy meets the policy's other conditions. Ask whether a 503A pharmacy (not a 503B outsourcing facility) fills your order, and in what device.
- The one device the policy's conditions name for the package is a 510(k)-cleared syringe, and nasal spray pumps go unmentioned, so ask the pharmacy how it dispenses the spray.
- FDA listed semax in Category 2 from September 29, 2023 to April 22, 2026. It is not FDA-approved.
More detail: how the HHS policy works, semax nasal spray, and semax vs selank.
Compare the top providers at a glance
Logos, our editorial rating, price, the form each clinic sells, and coverage. Forms outside the HHS policy are marked “not covered.”
- ★ Editor's PickFrom /mo$229Coverage50 statesForm soldInjection · not covered
- Best BudgetFrom /mo$109Coverage47 statesForm soldNasal spray
- From /moCheck pricingCoverageCheck intakeForm soldNasal spray
- From /mo$109CoverageCheck intakeForm soldNasal spray
- From /moCheck pricingCoverageCheck intakeForm soldNasal spray
- From /moCheck pricingCoverage28 statesForm soldNasal spray
compounded peptides priced up front, including KPV, MOTS-c, epitalon and semax nasal spray
From /mo$133CoverageCheck intakeForm soldNasal spray
| Provider | Rating | From /mo | Form sold | Coverage | |
|---|---|---|---|---|---|
★ Editor's Pick | $229 | Injection · not covered | 50 states | Visit → | |
Best Budget | $109 | Nasal spray | 47 states | Visit → | |
 | Check pricing | Nasal spray | Check intake | Visit → | |
 | $109 | Nasal spray | Check intake | Visit → | |
 | Check pricing | Nasal spray | Check intake | Visit → | |
 | Check pricing | Nasal spray | 28 states | Visit → | |
 compounded peptides priced up front, including KPV, MOTS-c, epitalon and semax nasal spray | $133 | Nasal spray | Check intake | Visit → |
Each checked against the provider’s own site.
Providers that don’t post pricing up front score lower on Value and carry a cost-transparency note in their review. Read the full methodology →
Detailed Reviews
A note on prices below: any dollar figure in these provider summaries refers to that clinic’s GLP‑1 weight-loss program, not to Semax. The Semax price is the one beside each clinic in the comparison table above, read from that clinic’s own product page. Where it reads “Check pricing”, the clinic prescribes Semax but publishes no price for it — you are quoted after the consultation.
Pepti
Pepti is a Delaware-registered telehealth platform selling doctor-prescribed compounded peptides and GLP-1s, with a published shipping list of 49 states plus DC. Injectable semaglutide starts at $99 and tirzepatide at $159 per 28-day supply, rising with dose to $199 and $319. Each price covers medication, physician review, labs, refill management and shipping, with no membership fee. Pepti is a platform, not a prescriber, and does not bill insurance.
Score Breakdown
Pros
- ✓Injectable semaglutide starts at $99 and tirzepatide at $159 all-in, with no membership fee on top.
- ✓Publishes the exact price for every dose of both drugs, so you can see what titrating up will cost before you start.
- ✓Publishes a shipping list of 49 states plus DC, and a provider denial means a full refund.
- ✓Names the reviewing physician, Dr. Gene Lee MD, and posts third-party sterility and potency results by lot.
Cons
- ✗Billed every 28 days rather than monthly, so you pay 13 times a year, not 12.
- ✗Price rises with dose: semaglutide tops out at $199 and tirzepatide at $319 per supply.
- ✗The site says it serves 50 states, but its own list leaves out Oklahoma and counts DC instead.
- ✗No compounding pharmacy is named in advance; you only learn it from your medication label.
- ✗The listed address, a Newark Delaware suite, is a shared registered-agent address rather than a clinical office.
- ✗Cash-pay only with no insurance billing, and medication can't be refunded once it ships.
OurView Health
OurView Health is an online telehealth platform for weight loss, hormone therapy and wellness, with care from licensed providers through the Telegra network. Compounded semaglutide is $109/mo and tirzepatide $129/mo at any prescribed dose, or $99 and $119/mo on a 3-month prepay, with no membership or shipping fee. Medication is compounded by Boudreaux's New Drug Store, a 503A pharmacy in Louisiana. Service covers 46 states plus DC.
Score Breakdown
Pros
- ✓Low flat pricing: compounded semaglutide $109/mo and tirzepatide $129/mo at any prescribed dose
- ✓No membership fee and free shipping; a 3-month prepay drops the price to $99 or $119/mo
- ✓Names its pharmacy (Boudreaux's New Drug Store, a Louisiana 503A) and provider network (Telegra)
- ✓LegitScript seal on the site and a published list of states served
- ✓No contracts; your card is only charged after a provider approves treatment
Cons
- ✗Not available in Arkansas, Connecticut, Hawaii or New Jersey
- ✗Only 1-month or 3-month plans; the 3-month price is paid upfront
- ✗All sales are final once medication ships
- ✗The website is run by a marketing agency (Kickstart Social), and the operating company isn't named
- ✗Terms set Georgia law but require arbitration in San Diego, California
Ryze Rx
Ryze Rx is a prescription telehealth platform for weight loss, TRT and peptide therapy, prescribing through board-certified physicians and shipping from US-licensed compounding pharmacies. For weight loss it offers compounded injectable semaglutide and tirzepatide at $199/mo (or $499/$799 for a 3-month bundle), with physician consult and shipping included. The homepage advertises care in all 50 states.
Score Breakdown
Pros
- ✓Compounded semaglutide and tirzepatide both $199/mo, with $499/$799 three-month bundles
- ✓Physician consultation, ongoing clinical support and discreet shipping included with each prescription
- ✓Broad catalog beyond GLP-1: TRT plus peptides (BPC-157, sermorelin, NAD+, retatrutide and more)
- ✓Free shipping, 24hr prescription turnaround, FSA/HSA eligible; care advertised in all 50 states
Cons
- ✗Terms, Privacy Policy and HIPAA notice are dead links, so no legal entity, refund policy or governing law is disclosed
- ✗Pharmacy partners not named beyond 'US-licensed compounding pharmacies'
- ✗Homepage advertises GLP-1s 'from $149/mo' but the catalog lists $199/mo
- ✗On-site '4.9/5, 2,400+ reviews' is self-reported, not an independently confirmed rating
Enhanced
Enhanced, the brand behind the Enhanced Games, now sells clinician-prescribed compounded semaglutide and tirzepatide through independent telehealth providers, plus six newly launched peptide programs. Semaglutide is $129 month to month and tirzepatide $169, at every standard dose, falling to $89 and $129 on a 12-month plan billed upfront. Testosterone, supplements and other treatments sit alongside them.
Score Breakdown
Pros
- ✓Semaglutide from $129 month to month, or $89 a month on a 12-month plan
- ✓Tirzepatide from $169 month to month, or $129 a month on a 12-month plan
- ✓Partner pharmacies named: Red Rock, Health Warehouse, Precision Medicine and Triad Rx
- ✓Terms hold an advertised 'forever' price while you stay active on the same plan
- ✓Same price at every standard dose, with medication, clinician review and shipping listed as included
- ✓Six peptide programs, each from $119 month to month
Cons
- ✗The lowest standard-plan prices require paying for 12 months upfront: $1,068 for semaglutide, $1,548 for tirzepatide
- ✗Canceling only stops the next renewal; terms give no refund for the unused part of a billing period
- ✗Advertised 12-month savings use a list price; against its own monthly rate the real saving is $480
- ✗Shipping can take at least 10 business days; peptides 2-3 weeks
- ✗No state list published; availability is confirmed during intake
- ✗Prescribers are independent and not named until intake; no phone support listed
- ✗Compounded medications are not FDA-approved
- ✗Money-back guarantee has strict conditions, and Enhanced decides whether a request qualifies
EllieMD
EllieMD is a women-focused telehealth brand selling compounded GLP-1 and GLP-1/GIP formulas in 12-week supplies. Injections are $199/mo (GLP-1) and $249/mo (GLP-1/GIP) and oral drops $299 and $379, with provider care, shipping, nausea medication and labs included. A lower-dose microdose program is $229 and $239 with an 84-day minimum. Much of the wider catalog is peptides and supplements.
Score Breakdown
Pros
- ✓Both semaglutide and tirzepatide available
Cons
- ✗Every plan is a 12-week supply, so there is no way to buy a single month
How we rank & what counts as “legit”
Every provider in this ranking is scored against our published six-factor rubric[1] — value, effectiveness, user experience, trust & safety, accessibility, and support.
Brand-name Wegovy, Zepbound, Ozempic, and Mounjaro are separately FDA-approved under their own NDA numbers[4][5]. Published Phase 3 efficacy for semaglutide 2.4 mg (~14.9% mean weight loss over 68 weeks) comes from the STEP 1 trial[6], and for tirzepatide (~20.9% at the 15 mg dose over 72 weeks) from SURMOUNT-1[7]; the SURMOUNT-5 head-to-head published in 2025 compared the two directly[8].
Insurance coverage for anti-obesity medications varies widely by state Medicaid program and commercial plan[9][10]. Compounded and brand-name GLP-1s are generally FSA/HSA eligible with a prescription under IRS Publication 502[11].
Frequently Asked Questions
Sources & methodology (as of November 2026)
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 5.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 8.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
- 9.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 10.CMS — Medicaid prescription drug coverage policy (state-by-state)— Centers for Medicare & Medicaid Services.
- 11.IRS Publication 502 — Medical and Dental Expenses (HSA/FSA eligibility)— Internal Revenue Service.