From the FDA label (DailyMed)Verified 2026-07-12

Ozempic Storage & Handling

How to store semaglutide correctly — refrigeration range, room-temperature allowance, and what to do if it's been frozen or left in the light — transcribed from the FDA prescribing information.

WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more

Ozempic Storage at a Glance

Refrigerated (unopened)
36°F to 46°F (2°C to 8°C)
Room-temperature allowance
Pen (after first use): 59°F to 86°F (15°C to 30°C), or refrigerated, for up to 56 days. Prefilled syringe (before first use): 46°F to 86°F (8°C to 30°C) for up to 28 days.
Freezing
Do not freeze OZEMPIC. Do not use OZEMPIC if it has been frozen.
Light
Keep OZEMPIC away from heat and out of direct light; store it in the original carton until time of administration, and don't store it directly against the refrigerator's cooling element.

Source: Ozempic FDA prescribing information via DailyMed (SetID adec4fd2-6858-4c99-91d4-531f5f2a2d79), Section 16.2 How Supplied/Storage and Handling. Last verified 2026-07-12. This is summary information — read the full label and the patient instructions that came with your prescription.

Handling the pen or vial

Once you start using it: the in-use window is 56 days after first use (pen) / 28 days (prefilled syringe). Mark the date you first used it (on the device or your calendar) so you know exactly when to discard it — the label requires discarding after this window even if medicine remains.

Keep the pen or vial in its original carton whenever possible — this is what protects it from light, and doubles as a place to note the first-use date. Never store a pen with the needle attached between uses.

Traveling with Ozempic

A new, unused pen needs refrigeration; once you start using it, it can travel at room temperature for up to 56 days — just keep the cap on when it's not in use and out of direct heat and light. Write the first-use date on the pen or your calendar so you know when the 56-day clock runs out.

Related Ozempic guides

Ozempic dosing & titration →
The full FDA-label dose schedule, from starting dose to maintenance.
Ozempic side effects →
Common adverse reactions and the boxed warning, from the FDA label.

Compare every Ozempic provider

See current pricing, verification status, form, and states served across every vetted provider in one place.

View the full comparison tableBrowse the ranked directoryOzempic drug guide

Frequently Asked Questions

Store unopened Ozempic in the refrigerator at 36°F to 46°F (2°C to 8°C). Pen (after first use): 59°F to 86°F (15°C to 30°C), or refrigerated, for up to 56 days. Prefilled syringe (before first use): 46°F to 86°F (8°C to 30°C) for up to 28 days. Source: FDA label via DailyMed (SetID adec4fd2-6858-4c99-91d4-531f5f2a2d79), Section 16.2, verified 2026-07-12.
Yes, within limits. Pen (after first use): 59°F to 86°F (15°C to 30°C), or refrigerated, for up to 56 days. Prefilled syringe (before first use): 46°F to 86°F (8°C to 30°C) for up to 28 days. Once you start that clock, discard it after 56 days after first use (pen) / 28 days (prefilled syringe), even if some medicine remains.
Do not freeze OZEMPIC. Do not use OZEMPIC if it has been frozen. If you're not sure whether a dose was exposed to freezing temperatures, don't use it — check with your pharmacy about a replacement.
Keep OZEMPIC away from heat and out of direct light; store it in the original carton until time of administration, and don't store it directly against the refrigerator's cooling element.