Ozempic Dosing & Titration Schedule
The semaglutide starting dose, full titration ladder, maintenance dose, and maximum dose — transcribed from the FDA prescribing information.
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Ozempic Titration Schedule
The step-by-step dose-escalation ladder for Ozempic from the FDA label's Dosage & Administration section (DailyMed SetID adec4fd2-6858-4c99-91d4-531f5f2a2d79). Your prescriber sets your actual schedule — this is the label reference, not medical advice.
| Step | Dose | When |
|---|---|---|
| 1 | 0.25 mg once weekly | Weeks 1–4 (initiation only — not effective for glycemic control) |
| 2 | 0.5 mg once weekly | After 4 weeks on 0.25 mg |
| 3 | 1 mg once weekly | After at least 4 weeks on 0.5 mg, if more control is needed |
| 4 | 2 mg once weekly | After at least 4 weeks on 1 mg, if more control is needed |
Source: Ozempic FDA prescribing information via DailyMed (SetID adec4fd2-6858-4c99-91d4-531f5f2a2d79), Section 2 Dosage & Administration. Last verified 2026-06-01. This is summary information — read the full label and follow your prescriber's instructions.
Ozempic Dosing at a Glance
How to titrate safely
Increase the dose only after at least 4 weeks on the current dose, and only if more glycemic control is needed. Administer on the same day each week, at any time of day, with or without meals.
The guiding principle: only increase the dose if you're tolerating the current one, and slow down (or pause the escalation) if side effects flare. Going up faster than the label schedule does not speed up results — it mostly increases nausea and other GI side effects.
If you miss a dose or can't tolerate a step
Missed a dose? The late-dose window differs by drug. See our GLP-1 missed-dose rules by drug for the exact rule for Ozempic before doubling up or skipping.
Can't tolerate a dose increase? The label allows delaying escalation or staying on a lower dose. Read what to expect at each step on the Ozempic side effects page, then talk to your prescriber before changing your schedule.
Compare every Ozempic provider
A prescriber sets your dose and titration plan before prescribing. See current pricing, verification status, form, and states served across every vetted provider in one place.