Rebound weight gain

Definition

Rapid regain of body weight following GLP-1 discontinuation. The STEP-1 withdrawal extension (Wilding 2022 Diabetes Obes Metab, PMID 35441470) showed participants who stopped semaglutide 2.4 mg after 68 weeks regained two-thirds of their lost weight within one year, with restoration of pre-treatment metabolic risk markers. The data reframed GLP-1 obesity treatment as chronic-disease therapy, like blood-pressure medication, rather than a finite intervention.

STEP-1 withdrawal extension on our top studies list →

Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in Patient experience

• Plateau
• Microdosing
• Switching GLP-1s
• GLP-1 + anesthesia (preoperative)

Looking for more depth?

• STEP-1 withdrawal extension on our top studies list
• Browse the full GLP-1 glossary (61 terms across 8 categories)
• Research articles — primary-source deep dives
• Tools and calculators
• Compare GLP-1 telehealth providers