GLP-1 in pregnancy

Definition

All approved GLP-1 receptor agonists carry a pregnancy precaution and are recommended to be discontinued at least 2 months (semaglutide, given its long half-life) before a planned conception. Animal studies show developmental toxicity at human-equivalent doses. No randomized human-pregnancy data exist; observational registries are accumulating. Patients of reproductive age should use reliable contraception. Inadvertent GLP-1 exposure in early pregnancy is not a guaranteed indication for termination — discuss with a maternal-fetal medicine specialist.

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Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

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