Mounjaro Dosing & Titration Schedule
The tirzepatide starting dose, full titration ladder, maintenance dose, and maximum dose — transcribed from the FDA prescribing information.
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Mounjaro Titration Schedule
The step-by-step dose-escalation ladder for Mounjaro from the FDA label's Dosage & Administration section (DailyMed SetID d2d7da5d-ad07-4228-955f-cf7e355c8cc0). Your prescriber sets your actual schedule — this is the label reference, not medical advice.
| Step | Dose | When |
|---|---|---|
| 1 | 2.5 mg once weekly | Weeks 1–4 (initiation only — not for glycemic control) |
| 2 | 5 mg once weekly | After 4 weeks on 2.5 mg |
| 3 | Increase in 2.5 mg increments (7.5 / 10 / 12.5 / 15 mg) | After at least 4 weeks on the current dose, if more glycemic control is needed |
Source: Mounjaro FDA prescribing information via DailyMed (SetID d2d7da5d-ad07-4228-955f-cf7e355c8cc0), Section 2 Dosage & Administration. Last verified 2026-06-01. This is summary information — read the full label and follow your prescriber's instructions.
Mounjaro Dosing at a Glance
How to titrate safely
Increase in 2.5 mg increments only after at least 4 weeks on the current dose. Administer once weekly at any time of day, with or without meals; the weekly day can be changed if there are at least 72 hours between doses.
The guiding principle: only increase the dose if you're tolerating the current one, and slow down (or pause the escalation) if side effects flare. Going up faster than the label schedule does not speed up results — it mostly increases nausea and other GI side effects.
If you miss a dose or can't tolerate a step
Missed a dose? The late-dose window differs by drug. See our GLP-1 missed-dose rules by drug for the exact rule for Mounjaro before doubling up or skipping.
Can't tolerate a dose increase? The label allows delaying escalation or staying on a lower dose. Read what to expect at each step on the Mounjaro side effects page, then talk to your prescriber before changing your schedule.
Compare every Mounjaro provider
A prescriber sets your dose and titration plan before prescribing. See current pricing, verification status, form, and states served across every vetted provider in one place.